The University of Southampton
University of Southampton Institutional Repository

The clinical effectiveness and cost-effectiveness of gemcitabine for metastatic breast cancer: a systematic review and economic evaluation

Takeda, A.L., Jones, J., Loveman, Emma, Tan, S.C. and Clegg, A.J. (2007) The clinical effectiveness and cost-effectiveness of gemcitabine for metastatic breast cancer: a systematic review and economic evaluation Health Technology Assessment, 11, (19), pp. 1-62. (doi:10.3310/hta11190). (PMID:17462169).

Record type: Article

Abstract

The review of clinical effectiveness is based on data from a single RCT that has not yet been fully published. While only tentative conclusions can be drawn from this, the evidence may indicate that treatment with gemcitabine and paclitaxel confers an improved outcome for patients in terms of survival and disease progression, but at the cost of increased toxicity. An economic model developed for this review reflects high costs per QALY for this treatment combination. The base-case analysis shows high ICERs, with costs per QALY gained close to 60,000 pounds. Adopting a more realistic treatment protocol, with chemotherapy limited to a maximum of six cycles, gives a more favourable cost-effectiveness estimate. However, this was still higher than would usually be considered to be a cost-effective treatment from the NHS's perspective. Future research recommendations include an update of this review in 12-18 months' time, by which time the included RCT should be fully published. It would also be useful to compare gemcitabine with currently used treatments for metastatic breast cancer, including capecitabine and vinorelbine.

Full text not available from this repository.

More information

Published date: May 2007
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 194797
URI: http://eprints.soton.ac.uk/id/eprint/194797
ISSN: 1366-5278
PURE UUID: 77612d94-2396-4028-a88d-aa3a6230fd87

Catalogue record

Date deposited: 11 Aug 2011 10:28
Last modified: 18 Jul 2017 11:26

Export record

Altmetrics

Contributors

Author: A.L. Takeda
Author: J. Jones
Author: Emma Loveman
Author: S.C. Tan
Author: A.J. Clegg

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×