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Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation

Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation
Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation
ADV and PEG are associated with significant improvements in a number of biochemical, virological and histological outcomes in both HBeAg-positive and -negative patients. For a small proportion of patients this is associated with resolution of infection. For another proportion it leads to remission and a reduced risk of progressing to cirrhosis, hepatocellular carcinoma, liver transplant and death. For others who do not respond or who relapse, retreatment with another agent is necessary. The results of our cost-effectiveness analysis demonstrate that incremental costs per QALY for a range of comparisons were between 5994 pounds and 16,569 pounds and within the range considered by NHS decision-makers to represent good value for money. When subjected to sensitivity analysis, most costs per QALY estimates remained under 30,000 pounds. Further RCT evidence of the effectiveness of anti-viral treatment is required, particularly for subgroups of patients with different genotypes, patients with cirrhosis, patients from different ethnic groups, patients with co-infections (e.g. HIV, HCV) and co-morbidities, liver transplant patients and children and adolescents.
1366-5278
1-183
Shepherd, J.
dfbca97a-9307-4eee-bdf7-e27bcb02bc67
Jones, J.
270b303b-6bad-4be7-8ea0-63d0e8015c91
Takeda, A.
f6243016-c00a-46eb-bb0d-dbbbc4dcdd6e
Davidson, P.
531fc501-2ab0-4481-900e-2e7c0cc6424d
Price, A.
43084e97-b383-4dd5-9ae9-df4fc8626e99
Shepherd, J.
dfbca97a-9307-4eee-bdf7-e27bcb02bc67
Jones, J.
270b303b-6bad-4be7-8ea0-63d0e8015c91
Takeda, A.
f6243016-c00a-46eb-bb0d-dbbbc4dcdd6e
Davidson, P.
531fc501-2ab0-4481-900e-2e7c0cc6424d
Price, A.
43084e97-b383-4dd5-9ae9-df4fc8626e99

Shepherd, J., Jones, J., Takeda, A., Davidson, P. and Price, A. (2006) Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation. Health Technology Assessment, 10 (28), 1-183. (doi:10.3310/hta10280). (PMID:16904047)

Record type: Article

Abstract

ADV and PEG are associated with significant improvements in a number of biochemical, virological and histological outcomes in both HBeAg-positive and -negative patients. For a small proportion of patients this is associated with resolution of infection. For another proportion it leads to remission and a reduced risk of progressing to cirrhosis, hepatocellular carcinoma, liver transplant and death. For others who do not respond or who relapse, retreatment with another agent is necessary. The results of our cost-effectiveness analysis demonstrate that incremental costs per QALY for a range of comparisons were between 5994 pounds and 16,569 pounds and within the range considered by NHS decision-makers to represent good value for money. When subjected to sensitivity analysis, most costs per QALY estimates remained under 30,000 pounds. Further RCT evidence of the effectiveness of anti-viral treatment is required, particularly for subgroups of patients with different genotypes, patients with cirrhosis, patients from different ethnic groups, patients with co-infections (e.g. HIV, HCV) and co-morbidities, liver transplant patients and children and adolescents.

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Published date: August 2006
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 194801
URI: http://eprints.soton.ac.uk/id/eprint/194801
ISSN: 1366-5278
PURE UUID: f5a8acbc-9cde-47cc-8737-3d4d3c238693
ORCID for J. Shepherd: ORCID iD orcid.org/0000-0003-1682-4330
ORCID for P. Davidson: ORCID iD orcid.org/0000-0003-0388-6356

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Date deposited: 11 Aug 2011 10:38
Last modified: 15 Mar 2024 03:15

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Contributors

Author: J. Shepherd ORCID iD
Author: J. Jones
Author: A. Takeda
Author: P. Davidson ORCID iD
Author: A. Price

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