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Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process

Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process
Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process
The rapid prototyping of a reversible and one step moulded compartmentalised neuron glass/PDMS device with a thin wall barrier directly adjacent to the reservoirs is presented. A simple moulding technique to produce these devices results in a barrier of 560 ?m where the 3 ?m deep by 8 ?m wide channels can be reversibly fabricated in either the glass base or PDMS compartmentalised mould depending on the type of application required. Using glass substrates with commercially laser engraved microchannels, both the PDMS planar and PDMS channelled device can be easily fabricated in a standard laboratory. The compartmentalised device has several advantages including good experimental accessibility and versatility with a variety of end user applications.
1473-0197
3001-3005
Arundell, Martin
e24d3405-a436-4d65-a6e4-2939ede79678
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Arundell, Martin
e24d3405-a436-4d65-a6e4-2939ede79678
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25

Arundell, Martin, Perry, V. Hugh and Newman, Tracey A. (2011) Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process. Lab on a Chip, 11 (17), 3001-3005. (doi:10.1039/C1LC20120D). (PMID:21776485)

Record type: Article

Abstract

The rapid prototyping of a reversible and one step moulded compartmentalised neuron glass/PDMS device with a thin wall barrier directly adjacent to the reservoirs is presented. A simple moulding technique to produce these devices results in a barrier of 560 ?m where the 3 ?m deep by 8 ?m wide channels can be reversibly fabricated in either the glass base or PDMS compartmentalised mould depending on the type of application required. Using glass substrates with commercially laser engraved microchannels, both the PDMS planar and PDMS channelled device can be easily fabricated in a standard laboratory. The compartmentalised device has several advantages including good experimental accessibility and versatility with a variety of end user applications.

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Published date: 20 July 2011
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 194957
URI: https://eprints.soton.ac.uk/id/eprint/194957
ISSN: 1473-0197
PURE UUID: 9f2773fc-2436-4c36-be0c-fbe17cdb4f95
ORCID for Tracey A. Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 15 Aug 2011 08:36
Last modified: 10 Jan 2019 01:37

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