Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
Background: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. Methods: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442).
Results: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV1 % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores.
Conclusions: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity.
asthma, brain-derived neurotrophic factor, polymorphism, bdnf
343-349
Szczepankiewicz, Aleksandra
54b47a55-9a85-44c8-b4b9-dea4a8d9fe73
Rose-Zerilli, Matthew J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Barton, Sheila J.
4f674382-ca0b-44ad-9670-e71a0b134ef0
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
September 2009
Szczepankiewicz, Aleksandra
54b47a55-9a85-44c8-b4b9-dea4a8d9fe73
Rose-Zerilli, Matthew J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Barton, Sheila J.
4f674382-ca0b-44ad-9670-e71a0b134ef0
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Szczepankiewicz, Aleksandra, Rose-Zerilli, Matthew J., Barton, Sheila J., Holgate, Stephen T. and Holloway, John W.
(2009)
Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
International Archives of Allergy and Immunology, 149 (4), .
(doi:10.1159/000205580).
(PMID:19295238)
Abstract
Background: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. Methods: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442).
Results: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV1 % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores.
Conclusions: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity.
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Published date: September 2009
Keywords:
asthma, brain-derived neurotrophic factor, polymorphism, bdnf
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 195115
URI: http://eprints.soton.ac.uk/id/eprint/195115
ISSN: 1018-2438
PURE UUID: f1ca5a76-26e1-4853-951d-46439e139206
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Date deposited: 16 Aug 2011 15:31
Last modified: 15 Mar 2024 03:36
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Author:
Aleksandra Szczepankiewicz
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