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Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families

Szczepankiewicz, Aleksandra, Rose-Zerilli, Matthew J., Barton, Sheila J., Holgate, Stephen T. and Holloway, John W. (2009) Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families International Archives of Allergy and Immunology, 149, (4), pp. 343-349. (doi:10.1159/000205580). (PMID:19295238).

Record type: Article


Background: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. Methods: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442).

Results: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV1 % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores.

Conclusions: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity.

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Published date: September 2009
Keywords: asthma, brain-derived neurotrophic factor, polymorphism, bdnf
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 195115
ISSN: 1018-2438
PURE UUID: f1ca5a76-26e1-4853-951d-46439e139206
ORCID for Sheila J. Barton: ORCID iD
ORCID for John W. Holloway: ORCID iD

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Date deposited: 16 Aug 2011 15:31
Last modified: 18 Jul 2017 11:25

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Author: Aleksandra Szczepankiewicz

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