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Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma

Bousquet, Jean, Mantzouranis, Eva, Cruz, Alvaro A., Aït-Khaled, Nadia, Baena-Cagnani, Carlos E., Bleecker, Eugene R., Brightling, Chris E., Burney, Peter, Bush, Andrew, Busse, William W., Casale, Thomas B., Chan-Yeung, Moira, Chen, Rongchang, Chowdhury, Badrul, Chung, Kian Fan, Dahl, Ronald, Drazen, Jeffrey M., Fabbri, Leonardo M., Holgate, Stephen T., Kauffmann, Francine, Haahtela, Tari, Khaltaev, Nikolaï, Kiley, James P., Masjedi, Mohammad R., Mohammad, Yousser, O'Byrne, Paul, Partridge, Martyn R., Rabe, Klaus F., Togias, Alkis, van Weel, Christiaan, Wenzel, Sally, Zhong, Nanshan and Zuberbier, Torsten (2010) Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma Journal of Allergy and Clinical Immunology, 126, (5), pp. 926-938. (doi:10.1016/j.jaci.2010.07.019). (PMID:21050941).

Record type: Article


Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic groups and countries. It is estimated that around 250,000 people die prematurely each year as a result of asthma. Concepts of asthma severity and control are important in evaluating patients and their response to treatment, as well as for public health, registries, and research (clinical trials, epidemiologic, genetic, and mechanistic studies), but the terminology applied is not standardized, and terms are often used interchangeably. A common international approach is favored to define severe asthma, uncontrolled asthma, and when the 2 coincide, although adaptation may be required in accordance with local conditions. A World Health Organization meeting was convened April 5-6, 2009, to propose a uniform definition of severe asthma. An article was written by a group of experts and reviewed by the Global Alliance against Chronic Respiratory Diseases review group. Severe asthma is defined by the level of current clinical control and risks as "Uncontrolled asthma which can result in risk of frequent severe exacerbations (or death) and/or adverse reactions to medications and/or chronic morbidity (including impaired lung function or reduced lung growth in children)." Severe asthma includes 3 groups, each carrying different public health messages and challenges: (1) untreated severe asthma, (2) difficult-to-treat severe asthma, and (3) treatment-resistant severe asthma. The last group includes asthma for which control is not achieved despite the highest level of recommended treatment and asthma for which control can be maintained only with the highest level of recommended treatment.

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Published date: November 2010
Keywords: asthma, severity, control, risk, definition, gard
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 195235
ISSN: 0091-6749
PURE UUID: 5cb45d2b-946d-4294-ab63-40d4613b4ec7

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Date deposited: 17 Aug 2011 14:15
Last modified: 18 Jul 2017 11:25

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Author: Jean Bousquet
Author: Eva Mantzouranis
Author: Alvaro A. Cruz
Author: Nadia Aït-Khaled
Author: Carlos E. Baena-Cagnani
Author: Eugene R. Bleecker
Author: Chris E. Brightling
Author: Peter Burney
Author: Andrew Bush
Author: William W. Busse
Author: Thomas B. Casale
Author: Moira Chan-Yeung
Author: Rongchang Chen
Author: Badrul Chowdhury
Author: Kian Fan Chung
Author: Ronald Dahl
Author: Jeffrey M. Drazen
Author: Leonardo M. Fabbri
Author: Francine Kauffmann
Author: Tari Haahtela
Author: Nikolaï Khaltaev
Author: James P. Kiley
Author: Mohammad R. Masjedi
Author: Yousser Mohammad
Author: Paul O'Byrne
Author: Martyn R. Partridge
Author: Klaus F. Rabe
Author: Alkis Togias
Author: Christiaan van Weel
Author: Sally Wenzel
Author: Nanshan Zhong
Author: Torsten Zuberbier

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