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Effect of omalizumab on peripheral blood eosinophilia in allergic asthma

Record type: Article

Eosinophilia is an established marker of asthma-related inflammation. We assessed the effect of omalizumab on peripheral blood eosinophil counts using a pooled analysis of data from five randomized, double-blind, placebo-controlled studies in patients with moderate-to-severe persistent allergic asthma receiving moderate-to-high-dose inhaled corticosteroids (omalizumab, n=1136; placebo, n=1100). Relationships between omalizumab, peripheral blood eosinophils, serum free IgE concentrations and clinical outcomes were explored. Baseline mean eosinophil counts were similar in each treatment group. Post-treatment eosinophil counts were significantly reduced from baseline in the omalizumab group (p<0.0001) but were not significantly different in the placebo group. Greater reductions in eosinophil counts were observed in patients who had post-treatment free IgE levels <50ng/mL. Three studies included steroid-stable and steroid-reduction phases. At the end of each phase in these studies, a significantly greater reduction in eosinophil counts was achieved in the omalizumab group compared with the placebo group (p<0.0001). A consistent pattern of improved clinical outcomes/decreased eosinophils and worsened clinical outcomes/increased eosinophils was observed for both omalizumab and placebo treatment groups. The findings from our analysis of a large patient population are consistent with earlier reports of the inhibitory effect of omalizumab on eosinophils.

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Citation

Massanari, M., Holgate, S.T., Busse, W.W., Jimenez, P., Kianifard, F. and Zeldin, R. (2010) Effect of omalizumab on peripheral blood eosinophilia in allergic asthma Respiratory Medicine, 104, (2), pp. 188-196. (doi:10.1016/j.rmed.2009.09.011). (PMID:19846286).

More information

Published date: February 2010
Keywords: omalizumab, ige, eosinophils, allergy, asthma
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 195245
URI: http://eprints.soton.ac.uk/id/eprint/195245
PURE UUID: 957e5cac-c776-4537-acf1-b8094bd284a4

Catalogue record

Date deposited: 17 Aug 2011 14:49
Last modified: 18 Jul 2017 11:25

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Contributors

Author: M. Massanari
Author: S.T. Holgate
Author: W.W. Busse
Author: P. Jimenez
Author: F. Kianifard
Author: R. Zeldin

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