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Site distribution in resin beads as determined by confocal Raman spectroscopy

Site distribution in resin beads as determined by confocal Raman spectroscopy
Site distribution in resin beads as determined by confocal Raman spectroscopy
Scanning confocal Raman spectroscopy was used to study the distribution of reactive sites within a resin bead used for solid-phase synthesis. The distribution of NH2 groups in aminomethylated polystyrene resin (APS) was determined by doping with varying amounts of 4-cyanobenzoic acid. The extent of loading was determined by both elemental analysis and ninhydrin assays. The spatial distribution of the coupled 4-cyanobenzamide within the bead was determined to an in-plane resolution of 1µm and depth resolution of about 4µm, using; the strong Raman CN stretching vibrational transition at 2230 cm(-1). Dry and swollen beads were studied and the distribution was found to be essentially uniform throughout the bead in all cases.
combinatorial chemistry, confocal microscopy, polymers, raman spectroscopy, solid-phase synthesis, phase peptide-synthesis
0947-6539
3880-3883
Kress, Jürgen
2a20514a-6783-43d3-9301-b6e7a7fbe3e9
Rose, Abigail
7e1f0e36-2ad5-4e29-b9b9-756484f1f8c6
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Brocklesby, William S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, Mark
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Mellor, Geoff W.
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Bradley, Mark
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Kress, Jürgen
2a20514a-6783-43d3-9301-b6e7a7fbe3e9
Rose, Abigail
7e1f0e36-2ad5-4e29-b9b9-756484f1f8c6
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Brocklesby, William S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, Mark
9b8816c5-3cc6-462c-ac81-042dc167db53
Mellor, Geoff W.
e4f96438-f331-408e-8fe5-0862fc4c4c03
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900

Kress, Jürgen, Rose, Abigail, Frey, Jeremy G., Brocklesby, William S., Ladlow, Mark, Mellor, Geoff W. and Bradley, Mark (2001) Site distribution in resin beads as determined by confocal Raman spectroscopy. Chemistry - A European Journal, 7 (18), 3880-3883.

Record type: Article

Abstract

Scanning confocal Raman spectroscopy was used to study the distribution of reactive sites within a resin bead used for solid-phase synthesis. The distribution of NH2 groups in aminomethylated polystyrene resin (APS) was determined by doping with varying amounts of 4-cyanobenzoic acid. The extent of loading was determined by both elemental analysis and ninhydrin assays. The spatial distribution of the coupled 4-cyanobenzamide within the bead was determined to an in-plane resolution of 1µm and depth resolution of about 4µm, using; the strong Raman CN stretching vibrational transition at 2230 cm(-1). Dry and swollen beads were studied and the distribution was found to be essentially uniform throughout the bead in all cases.

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Published date: 17 September 2001
Keywords: combinatorial chemistry, confocal microscopy, polymers, raman spectroscopy, solid-phase synthesis, phase peptide-synthesis

Identifiers

Local EPrints ID: 19534
URI: http://eprints.soton.ac.uk/id/eprint/19534
ISSN: 0947-6539
PURE UUID: bc2066db-b263-499b-abe7-e190a89401c1
ORCID for Jeremy G. Frey: ORCID iD orcid.org/0000-0003-0842-4302
ORCID for William S. Brocklesby: ORCID iD orcid.org/0000-0002-2123-6712

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Date deposited: 15 Feb 2006
Last modified: 17 Dec 2019 02:04

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Contributors

Author: Jürgen Kress
Author: Abigail Rose
Author: Jeremy G. Frey ORCID iD
Author: Mark Ladlow
Author: Geoff W. Mellor
Author: Mark Bradley

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