The University of Southampton
University of Southampton Institutional Repository

Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses

Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
In an experimental model of diabetes and hypercholesterolemia, leukocyte activation was associated with augmented Lp-PLA2 expression. In vitro, Lp-PLA2 activity mediated leukocyte activation and inflammatory responses, whereas Lp-PLA2 inhibition abolished inflammatory responses induced by oxidized LDL. Collectively, these observations support a proatherogenic role for Lp-PLA2.
atherosclerosis, hypercholesterolemia, diabetes, inflammation, lipoprotein-associated phospholipase
0021-9150
54-62
Shi, Yi
45de4c85-68fd-4e77-a449-d821d48910c8
Zhang, Ping
2def4374-679d-41d1-bf3a-483028a73275
Zhang, LiFeng
63499a83-88aa-47dc-af52-0453a4c2ea81
Osman, Hashim
14f92bee-39f5-4748-89b0-b357fcacbe65
Mohler, Emile R.
55102026-9e58-47eb-bc5a-46d07fef0da0
Macphee, Colin
78420779-d9e5-41da-a137-d3313ce68011
Zalewski, Andrew
7d6541f9-926b-46b8-b559-806f16fe91b8
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilensky, Robert L.
4239c854-b7ea-4a2c-8461-de273728da78
Shi, Yi
45de4c85-68fd-4e77-a449-d821d48910c8
Zhang, Ping
2def4374-679d-41d1-bf3a-483028a73275
Zhang, LiFeng
63499a83-88aa-47dc-af52-0453a4c2ea81
Osman, Hashim
14f92bee-39f5-4748-89b0-b357fcacbe65
Mohler, Emile R.
55102026-9e58-47eb-bc5a-46d07fef0da0
Macphee, Colin
78420779-d9e5-41da-a137-d3313ce68011
Zalewski, Andrew
7d6541f9-926b-46b8-b559-806f16fe91b8
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilensky, Robert L.
4239c854-b7ea-4a2c-8461-de273728da78

Shi, Yi, Zhang, Ping, Zhang, LiFeng, Osman, Hashim, Mohler, Emile R., Macphee, Colin, Zalewski, Andrew, Postle, Anthony and Wilensky, Robert L. (2007) Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses. Atherosclerosis, 191 (1), 54-62. (doi:10.1016/j.atherosclerosis.2006.05.001). (PMID:16765356)

Record type: Article

Abstract

In an experimental model of diabetes and hypercholesterolemia, leukocyte activation was associated with augmented Lp-PLA2 expression. In vitro, Lp-PLA2 activity mediated leukocyte activation and inflammatory responses, whereas Lp-PLA2 inhibition abolished inflammatory responses induced by oxidized LDL. Collectively, these observations support a proatherogenic role for Lp-PLA2.

Full text not available from this repository.

More information

Published date: March 2007
Keywords: atherosclerosis, hypercholesterolemia, diabetes, inflammation, lipoprotein-associated phospholipase
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 195577
URI: https://eprints.soton.ac.uk/id/eprint/195577
ISSN: 0021-9150
PURE UUID: 9f45af84-b32e-496c-aa4c-afab75bf4b3f
ORCID for Anthony Postle: ORCID iD orcid.org/0000-0001-7361-0756

Catalogue record

Date deposited: 23 Aug 2011 11:12
Last modified: 29 Aug 2019 00:56

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×