Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses
In an experimental model of diabetes and hypercholesterolemia, leukocyte activation was associated with augmented Lp-PLA2 expression. In vitro, Lp-PLA2 activity mediated leukocyte activation and inflammatory responses, whereas Lp-PLA2 inhibition abolished inflammatory responses induced by oxidized LDL. Collectively, these observations support a proatherogenic role for Lp-PLA2.
atherosclerosis, hypercholesterolemia, diabetes, inflammation, lipoprotein-associated phospholipase
54-62
Shi, Yi
45de4c85-68fd-4e77-a449-d821d48910c8
Zhang, Ping
2def4374-679d-41d1-bf3a-483028a73275
Zhang, LiFeng
63499a83-88aa-47dc-af52-0453a4c2ea81
Osman, Hashim
14f92bee-39f5-4748-89b0-b357fcacbe65
Mohler, Emile R.
55102026-9e58-47eb-bc5a-46d07fef0da0
Macphee, Colin
78420779-d9e5-41da-a137-d3313ce68011
Zalewski, Andrew
7d6541f9-926b-46b8-b559-806f16fe91b8
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilensky, Robert L.
4239c854-b7ea-4a2c-8461-de273728da78
March 2007
Shi, Yi
45de4c85-68fd-4e77-a449-d821d48910c8
Zhang, Ping
2def4374-679d-41d1-bf3a-483028a73275
Zhang, LiFeng
63499a83-88aa-47dc-af52-0453a4c2ea81
Osman, Hashim
14f92bee-39f5-4748-89b0-b357fcacbe65
Mohler, Emile R.
55102026-9e58-47eb-bc5a-46d07fef0da0
Macphee, Colin
78420779-d9e5-41da-a137-d3313ce68011
Zalewski, Andrew
7d6541f9-926b-46b8-b559-806f16fe91b8
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilensky, Robert L.
4239c854-b7ea-4a2c-8461-de273728da78
Shi, Yi, Zhang, Ping, Zhang, LiFeng, Osman, Hashim, Mohler, Emile R., Macphee, Colin, Zalewski, Andrew, Postle, Anthony and Wilensky, Robert L.
(2007)
Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses.
Atherosclerosis, 191 (1), .
(doi:10.1016/j.atherosclerosis.2006.05.001).
(PMID:16765356)
Abstract
In an experimental model of diabetes and hypercholesterolemia, leukocyte activation was associated with augmented Lp-PLA2 expression. In vitro, Lp-PLA2 activity mediated leukocyte activation and inflammatory responses, whereas Lp-PLA2 inhibition abolished inflammatory responses induced by oxidized LDL. Collectively, these observations support a proatherogenic role for Lp-PLA2.
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Published date: March 2007
Keywords:
atherosclerosis, hypercholesterolemia, diabetes, inflammation, lipoprotein-associated phospholipase
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 195577
URI: http://eprints.soton.ac.uk/id/eprint/195577
ISSN: 0021-9150
PURE UUID: 9f45af84-b32e-496c-aa4c-afab75bf4b3f
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Date deposited: 23 Aug 2011 11:12
Last modified: 15 Mar 2024 02:32
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Author:
Yi Shi
Author:
Ping Zhang
Author:
LiFeng Zhang
Author:
Hashim Osman
Author:
Emile R. Mohler
Author:
Colin Macphee
Author:
Andrew Zalewski
Author:
Robert L. Wilensky
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