Recent advances in alveolar biology: some new looks at the alveolar interface

Possmayer, Fred, Hall, Stephen B., Haller, Thomas, Petersen, Nils O., Zuo, Yi Y., Bernardino de la Serna, Jorge, Postle, Anthony D., Veldhuizen, Ruud A.W. and Orgeig, Sandra (2010) Recent advances in alveolar biology: some new looks at the alveolar interface. [in special issue: Supplement of the 2nd International Congress of Respiratory Science] Respiratory Physiology & Neurobiology, 173, supplement 1, S55-S64. (doi:10.1016/j.resp.2010.02.014). (PMID:20206718)

Abstract

This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.

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Contributors

Author: Anthony D. Postle

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