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Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases

Edwards, Alexander J.P. and Pender, Sylvia L.F. (2011) Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases Biochemical Society Transactions, 39, (4), pp. 1092-1095. (PMID:21787354).

Record type: Article


IBDs (inflammatory bowel diseases) are lifelong manifestations that significantly impair the quality of life of those who suffer from them. Although many therapies are now available, including immunomodulatory drugs such as Infliximab which have efficacy in IBD, not all patients respond and some patients generate autoantibodies against these drugs. Hence the search for novel treatments is ongoing. HDACs (histone deacetylases) are responsible for condensation of chromatin in the nucleus of cells and inhibition of gene transcription and are often dysregulated during cancer. HDAC inhibitors allow normal gene transcription to be restored and provide attractive therapeutic options, as they have been shown to be anti-inflammatory and anti-proliferative in cancer. Indeed, two HDAC inhibitors have been recently approved for the treatment of cutaneous T-cell lymphoma in the U.S.A. Recent research using animal models has shown that HDAC inhibitors may have a beneficial effect in colitis by boosting levels of Foxp3+ (forkhead box P3+) T-regulatory cells that dampen inflammation. In the present paper, we outline the background to IBD, HDACs and their inhibitors as well as discussing their current use in models of IBD.

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Published date: 1 August 2011
Keywords: crohn's disease, forkhead box p3 (foxp3), histone deacetylase, inflammatory bowel disease, ulcerative colitis
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 195603
ISSN: 0300-5127
PURE UUID: 218bca15-5721-4f65-b93c-3de2f123bfc5
ORCID for Sylvia L.F. Pender: ORCID iD

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Date deposited: 23 Aug 2011 14:11
Last modified: 18 Jul 2017 11:24

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Author: Alexander J.P. Edwards

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