Structural and functional uncoupling of liver performance in the Fontan circulation

Guha, Indra, Bokhandi, Sumit, Ahmad, Zaheer, Sheron, Nick, Cope, Richard, Marshall, Caroline and Veldtman, Gruschen (2011) Structural and functional uncoupling of liver performance in the Fontan circulation. International Journal of Cardiology. (doi:10.1016/j.ijcard.2011.06.062). (PMID:21788088) (In Press)

Abstract

Background: The liver is known to be structurally abnormal in long-standing Fontan circulation. The degree of liver dysfunction associated with such abnormalities is however largely unknown. We assessed structural changes (serum fibrosis markers) and function (indocyanine green clearance (ICG)) in Fontan patients.

Methods: 21 stable Fontan patients were prospectively assessed and compared with 8 histologically proven compensated viral cirrhotic patients. All subjects had standard liver profile, “Enhanced Liver Fibrosis” (ELF) score (including hyaluronic acid, aminoterminal type III procollagen peptide P3NP and tissue inhibitor of metalloproteinase TIMP-1 levels), and ICG using the LiMON Device. Plasma disappearance rate (PDR) and 15-minute retention (R15) were recorded after ICG infusion.

Results: Indocyanine clearance and retention (PDR and R15) were similar between Fontan and compensated cirrhotic patients (17 ± 5 vs 18 ± 6 (p = 0.75) and 11 ± 10 vs 10 ± 10 (p = 0.75)), as was degree of fibrosis (7.97 ± 1.16 vs 9.0 ± 1.43, p = NS). There was a positive correlation between PDR and ELF (R = 0.77, p = 0.028) as well as R15 and ELF (R = 0.905, p = 0.002) in the viral cirrhotics but not in the Fontan group. (R = ? 0.243, p = 0.302; and R = 0.226, p = 0.338). PDR (17 ± 5) and R15 (11 ± 10) were not significantly different in Fontan as compared with the established cirrhotics.

Conclusions: Fontan patients have similar global hepatic function and fibrosis as compared with viral cirrhotic patients. However in Fontan patients, fibrosis was not closely correlated with global liver function, whereas viral cirrhotic patients exhibited a close correlation between function and fibrosis.

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Contributors

Author: Nick Sheron

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