Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.
resin, solid phase synthesis, trypanothione reductase
combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding
515-518
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
15 January 2001
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Orain, D. and Bradley, M.
(2001)
Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening.
Tetrahedron Letters, 42 (3), .
(doi:10.1016/S0040-4039(00)02009-8).
Abstract
Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.
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Published date: 15 January 2001
Keywords:
resin, solid phase synthesis, trypanothione reductase
combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding
Identifiers
Local EPrints ID: 19584
URI: http://eprints.soton.ac.uk/id/eprint/19584
ISSN: 0040-4039
PURE UUID: a753c49c-37f1-4200-9dcb-dc98c60d4f42
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Date deposited: 14 Feb 2006
Last modified: 15 Mar 2024 06:17
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Contributors
Author:
D. Orain
Author:
M. Bradley
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