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Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening

Record type: Article

Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.

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Citation

Orain, D. and Bradley, M. (2001) Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening Tetrahedron Letters, 42, (3), pp. 515-518. (doi:10.1016/S0040-4039(00)02009-8).

More information

Published date: 15 January 2001
Keywords: resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding

Identifiers

Local EPrints ID: 19584
URI: http://eprints.soton.ac.uk/id/eprint/19584
ISSN: 0040-4039
PURE UUID: a753c49c-37f1-4200-9dcb-dc98c60d4f42

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Date deposited: 14 Feb 2006
Last modified: 17 Jul 2017 16:31

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Contributors

Author: D. Orain
Author: M. Bradley

University divisions


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