Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening


Orain, D. and Bradley, M. (2001) Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening Tetrahedron Letters, 42, (3), pp. 515-518. (doi:10.1016/S0040-4039(00)02009-8).

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Description/Abstract

Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4039(00)02009-8
ISSNs: 0040-4039 (print)
Keywords: resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding
Subjects:
ePrint ID: 19584
Date :
Date Event
15 January 2001Published
Date Deposited: 14 Feb 2006
Last Modified: 16 Apr 2017 23:01
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/19584

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