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Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening

Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.
resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding
0040-4039
515-518
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d

Orain, D. and Bradley, M. (2001) Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening. Tetrahedron Letters, 42 (3), 515-518. (doi:10.1016/S0040-4039(00)02009-8).

Record type: Article

Abstract

Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.

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More information

Published date: 15 January 2001
Keywords: resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding

Identifiers

Local EPrints ID: 19584
URI: http://eprints.soton.ac.uk/id/eprint/19584
ISSN: 0040-4039
PURE UUID: a753c49c-37f1-4200-9dcb-dc98c60d4f42

Catalogue record

Date deposited: 14 Feb 2006
Last modified: 15 Jul 2019 19:27

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