Pulmonary clearance rate of two chemically different forms of inhaled pertechnetate
Pulmonary clearance rate of two chemically different forms of inhaled pertechnetate
Attempts to image the pulmonary deposition site of radiolabeled aerosols delivered by dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs) using single photon emission computed tomography (SPECT) have been limited by the rapid pulmonary clearance of radiolabel. To determine whether aqueous solubility of the radiolabel is a significant factor, the pulmonary clearance rates of two chemically different forms of Tc-99m were calculated. A dry powder formulation of terbutaline sulphate was radiolabeled for inhalation by Turbuhaler (AstraZeneca) using the water-soluble salt sodium pertechnetate and the water-insoluble salt tetraphenylarsonium pertechnetate. A pilot study was conducted during which two control subjects each inhaled the two radiolabeled aerosols on separate days. Intrasubject clearance rates for the two species were very similar. It was therefore concluded that water insolubility of the pertechnetate salt alone was not enough to extend the lung residency time of the radiolabel.
pulmonary clearance, radiolabel, pertechnetate, aerosol, dry powder
terbutaline sulfate, aerosol deposition, absorption, delivery, lung, drugs, turbuhaler, monolayers, transport, insulin
209-215
Walker, Paul S.
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Conway, Joy H.
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Fleming, John S.
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Bondesson, Eva
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Borgstrom, Lars
0a5ca797-828e-4de9-a9d9-4f97c36fb94b
2001
Walker, Paul S.
d110682e-e70a-4afa-8042-3ec4f46428c3
Conway, Joy H.
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Fleming, John S.
9a23102d-6740-430a-ac74-89938b328ec3
Bondesson, Eva
ed20fdd1-cc5e-4189-8a79-87cfd4bd7091
Borgstrom, Lars
0a5ca797-828e-4de9-a9d9-4f97c36fb94b
Walker, Paul S., Conway, Joy H., Fleming, John S., Bondesson, Eva and Borgstrom, Lars
(2001)
Pulmonary clearance rate of two chemically different forms of inhaled pertechnetate.
Journal of Aerosol Medicine, 14 (2), .
(doi:10.1089/08942680152484135).
Abstract
Attempts to image the pulmonary deposition site of radiolabeled aerosols delivered by dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs) using single photon emission computed tomography (SPECT) have been limited by the rapid pulmonary clearance of radiolabel. To determine whether aqueous solubility of the radiolabel is a significant factor, the pulmonary clearance rates of two chemically different forms of Tc-99m were calculated. A dry powder formulation of terbutaline sulphate was radiolabeled for inhalation by Turbuhaler (AstraZeneca) using the water-soluble salt sodium pertechnetate and the water-insoluble salt tetraphenylarsonium pertechnetate. A pilot study was conducted during which two control subjects each inhaled the two radiolabeled aerosols on separate days. Intrasubject clearance rates for the two species were very similar. It was therefore concluded that water insolubility of the pertechnetate salt alone was not enough to extend the lung residency time of the radiolabel.
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Published date: 2001
Keywords:
pulmonary clearance, radiolabel, pertechnetate, aerosol, dry powder
terbutaline sulfate, aerosol deposition, absorption, delivery, lung, drugs, turbuhaler, monolayers, transport, insulin
Identifiers
Local EPrints ID: 19629
URI: http://eprints.soton.ac.uk/id/eprint/19629
PURE UUID: bbbdd19d-d715-49eb-8057-22e8c3013f31
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Date deposited: 13 Feb 2006
Last modified: 15 Mar 2024 06:17
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Author:
Paul S. Walker
Author:
Joy H. Conway
Author:
John S. Fleming
Author:
Eva Bondesson
Author:
Lars Borgstrom
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