The University of Southampton
University of Southampton Institutional Repository

Monitoring the prenatal detection of structural fetal congenital anomalies in England and Wales: register-based study

Boyd, Patricia A., Tonks, Ann M., Rankin, Judith, Rounding, Catherine, Wellesley, Dianna and Draper, Elizabeth S. (2011) Monitoring the prenatal detection of structural fetal congenital anomalies in England and Wales: register-based study Journal of Medical Screening, 18, (1), pp. 2-7. (doi:10.1258/jms.2011.010139). (PMID:21536809).

Record type: Article

Abstract

Objective: To provide current population-based prevalence and prenatal diagnosis rates (PND) for specified major congenital anomalies in England and Wales to enable monitoring of the Fetal Anomaly Screening Programme (FASP).
Design Secondary analysis of prospectively collected registry data.

Setting: Seven multiple-source, population-based congenital anomaly registers, members of the British Isles Network of Congenital Anomaly Registers (BINOCAR) in 2005 and 2006.

Population: 2,883 births with congenital anomalies from a total of 601,545 live and stillbirths.

Main outcome measures: PND and birth prevalence of selected congenital anomaly groups/subtypes (anencephaly, spina-bifida, serious cardiac, diaphragmatic hernia, gastroschisis, exomphalos, bilateral renal agenesis, lethal/severe skeletal dysplasia, cleft lip with or without cleft palate [CL + /–P]).

Results: Of the selected anomaly groups, the most frequently reported were serious cardiac (14.1 per 10,000 births [95% CI 13.0–15.2]) and CL + /–P (9.7 per 10,000 births [8.9–10.5]); the least frequent were bilateral renal agenesis and lethal/severe skeletal dysplasia (<1.5 per 10,000 births). The PND varied for different anomalies from 53.1% (95% CI 43.5–65.2) for serious cardiac anomalies to 99.6% (95% CI 97.9–100.0) for anencephaly. Least variation in PND rates was for anencephaly (range 98.9–100%) and gastroschisis (93.5–100%); greatest variation was for serious cardiac (43.5–65.2%) and lethal/severe skeletal dysplasias (50.0–100%).

Conclusions: BINOCAR registers can, uniquely, provide contemporary data on PND and birth prevalence rates to enable monitoring of the ultrasound component of FASP at a national and regional level, allowing comparisons between populations to be made, planning of resources facilitated and assistance for parents making informed decisions on whether to enter the screening programme.

Full text not available from this repository.

More information

Published date: March 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 196361
URI: http://eprints.soton.ac.uk/id/eprint/196361
PURE UUID: 13857402-ca4b-4277-83bb-d866b8f5db80

Catalogue record

Date deposited: 06 Sep 2011 13:29
Last modified: 18 Jul 2017 11:23

Export record

Altmetrics

Contributors

Author: Patricia A. Boyd
Author: Ann M. Tonks
Author: Judith Rankin
Author: Catherine Rounding
Author: Dianna Wellesley
Author: Elizabeth S. Draper

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×