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Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-? in the heart of the offspring

Record type: Article

Impaired flexibility in the use of substrates for energy production in the heart is implicated in cardiomyopathy. We investigated the effect of maternal protein restriction during pregnancy in rats on the transcription of key genes in cardiac lipid and carbohydrate metabolism in the offspring. Rats were fed protein-sufficient or protein-restricted (PR) diets during pregnancy. Triacylglycerol concentration in adult (day 105) heart was altered by maternal protein intake contingent on post-weaning fat intake and sex. mRNA expression of peroxisomal proliferator-activated receptor (PPAR)-? and carnitine palmitoyltransferase-1 was increased by the maternal PR diet in adult, but not neonatal, offspring. PPAR? promoter methylation was lower in adult and neonatal heart from PR offspring. These findings suggest that prenatal nutrition alters the future transcriptional regulation of cardiac energy metabolism in the offspring through changes in epigenetic regulation of specific genes. However, changes in gene functional changes may not be apparent in early life.

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Citation

Slater-Jefferies, J.L., Lillycrop, K.A., Townsend, P.A., Torrens, C., Hoile, S.P., Hanson, M.A. and Burdge, G.C. (2011) Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-? in the heart of the offspring Journal of Developmental Origins of Health and Disease, 2, (4), pp. 250-255. (doi:10.1017/S2040174410000425).

More information

Published date: 5 August 2011
Keywords: cardiomyopathy, epigenetic, heart, ppar, protein restriction
Organisations: Cancer Sciences, Human Development & Health, Centre for Biological Sciences

Identifiers

Local EPrints ID: 196371
URI: http://eprints.soton.ac.uk/id/eprint/196371
PURE UUID: e1a637cd-4058-4f42-95c0-f7a3ae71080f
ORCID for K.A. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 06 Sep 2011 14:22
Last modified: 18 Jul 2017 11:23

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Contributors

Author: J.L. Slater-Jefferies
Author: K.A. Lillycrop ORCID iD
Author: P.A. Townsend
Author: C. Torrens
Author: S.P. Hoile
Author: M.A. Hanson
Author: G.C. Burdge ORCID iD

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