Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

Yu, Zhanru, Alesso, Sonia, Pears, David, Worthington, Paul A., Luke, Richard W A. and Bradley, Mark (2001) Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines. Journal of the Chemical Society, Perkin Transactions 1, (16), 1947-1952. (doi:10.1039/b101395p).

Record type: Article

Abstract

A ketoester resin was developed as the basis for a selective scavenger for primary amines in the presence of secondary amines. The utility of the scavenger was demonstrated with a range of reductive amination chemistries with both mono- and diamines. The resin's specificity is based on the removal of the primary amines via their enamines.

This record has no associated files available for download.

More information

Published date: 21 August 2001

Keywords: small-molecule libraries, reductive amination, sodium triacetoxyborohydride, combinatorial synthesis, rapid purification, solution-phase, ion, strategies, aldehydes, scavenger

Learn more about Chemistry research