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Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines
Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines
A ketoester resin was developed as the basis for a selective scavenger for primary amines in the presence of secondary amines. The utility of the scavenger was demonstrated with a range of reductive amination chemistries with both mono- and diamines. The resin's specificity is based on the removal of the primary amines via their enamines.
small-molecule libraries, reductive amination, sodium triacetoxyborohydride, combinatorial synthesis, rapid purification, solution-phase, ion, strategies, aldehydes, scavenger
1947-1952
Yu, Zhanru
000ca0fd-d6e1-4b63-b90b-4b1ccc877409
Alesso, Sonia
433d3694-277f-4e1f-9a50-ce24956e4ba2
Pears, David
69d33806-b2ba-4af1-a8c2-4df93add46d9
Worthington, Paul A.
f5a2b471-1456-4d34-97e9-aaeae54401eb
Luke, Richard W A.
40a54db7-da5d-4851-9bd8-d59226ca195d
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Yu, Zhanru
000ca0fd-d6e1-4b63-b90b-4b1ccc877409
Alesso, Sonia
433d3694-277f-4e1f-9a50-ce24956e4ba2
Pears, David
69d33806-b2ba-4af1-a8c2-4df93add46d9
Worthington, Paul A.
f5a2b471-1456-4d34-97e9-aaeae54401eb
Luke, Richard W A.
40a54db7-da5d-4851-9bd8-d59226ca195d
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900

Yu, Zhanru, Alesso, Sonia, Pears, David, Worthington, Paul A., Luke, Richard W A. and Bradley, Mark (2001) Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines. Journal of the Chemical Society, Perkin Transactions 1, (16), 1947-1952. (doi:10.1039/b101395p).

Record type: Article

Abstract

A ketoester resin was developed as the basis for a selective scavenger for primary amines in the presence of secondary amines. The utility of the scavenger was demonstrated with a range of reductive amination chemistries with both mono- and diamines. The resin's specificity is based on the removal of the primary amines via their enamines.

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More information

Published date: 21 August 2001
Keywords: small-molecule libraries, reductive amination, sodium triacetoxyborohydride, combinatorial synthesis, rapid purification, solution-phase, ion, strategies, aldehydes, scavenger

Identifiers

Local EPrints ID: 19639
URI: http://eprints.soton.ac.uk/id/eprint/19639
PURE UUID: 6221fa65-8083-4f94-b15e-8ed76f8d1131

Catalogue record

Date deposited: 13 Feb 2006
Last modified: 15 Jul 2019 19:26

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