Modified electrodes for NADH oxidation and dehydrogenase-based biosensors
Modified electrodes for NADH oxidation and dehydrogenase-based biosensors
The direct electrochemical oxidation of beta-nicotinamide adenine dinucleotide (NADH) at clean electrodes proceeds through a radical cation intermediate at high overpotentials and is subject to rapid fouling. Consequently, there has been a considerable body of work over the last 20 years looking at ways in which to catalyse the reaction using a wide variety of different types of modified electrode. These studies have resulted in a good knowledge of the essential features required for efficient catalysis. In designing modified electrodes for NADH oxidation, it is not only important to identify suitable redox groups, which can catalyse NADH oxidation and can be attached to the electrode surface; it is also important to ensure facile charge transport between the immobilised redox sites in order to ensure that, in multilayer systems, the whole of the redox film contributes to the catalytic oxidation. One way to achieve this is by the use of electronically conducting polymers such as poly(aniline).
nadh oxidation, dehydrogenase, biosensor, charge transport, conducting polymers, chemically modified electrodes, electrocatalytic oxidation, compositefilms, redox polymers, kinetics, mechanism, switch, acid
117-122
Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Simon, E.
e381314d-f74a-4f11-847d-66404ccada06
Toh, C.S.
faf8cf8c-8408-4d88-9e64-e964a15b3872
15 May 2002
Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Simon, E.
e381314d-f74a-4f11-847d-66404ccada06
Toh, C.S.
faf8cf8c-8408-4d88-9e64-e964a15b3872
Bartlett, P.N., Simon, E. and Toh, C.S.
(2002)
Modified electrodes for NADH oxidation and dehydrogenase-based biosensors.
Bioelectrochemistry, 56 (1-2), .
(doi:10.1016/S1567-5394(02)00047-6).
Abstract
The direct electrochemical oxidation of beta-nicotinamide adenine dinucleotide (NADH) at clean electrodes proceeds through a radical cation intermediate at high overpotentials and is subject to rapid fouling. Consequently, there has been a considerable body of work over the last 20 years looking at ways in which to catalyse the reaction using a wide variety of different types of modified electrode. These studies have resulted in a good knowledge of the essential features required for efficient catalysis. In designing modified electrodes for NADH oxidation, it is not only important to identify suitable redox groups, which can catalyse NADH oxidation and can be attached to the electrode surface; it is also important to ensure facile charge transport between the immobilised redox sites in order to ensure that, in multilayer systems, the whole of the redox film contributes to the catalytic oxidation. One way to achieve this is by the use of electronically conducting polymers such as poly(aniline).
This record has no associated files available for download.
More information
Published date: 15 May 2002
Keywords:
nadh oxidation, dehydrogenase, biosensor, charge transport, conducting polymers, chemically modified electrodes, electrocatalytic oxidation, compositefilms, redox polymers, kinetics, mechanism, switch, acid
Identifiers
Local EPrints ID: 19666
URI: http://eprints.soton.ac.uk/id/eprint/19666
PURE UUID: 4454f111-601e-42df-a7a3-fafa5abfa1be
Catalogue record
Date deposited: 16 Feb 2006
Last modified: 16 Mar 2024 02:42
Export record
Altmetrics
Contributors
Author:
E. Simon
Author:
C.S. Toh
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
