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Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

McMurray, Rebecca J., Gadegaard, Nikolaj, Tsimbouri, P. Monica, Burgess, Karl V., McNamara, Laura E., Tare, Rahul, Murawski, Kate, Kingham, Emmajayne, Oreffo, Richard O.C. and Dalby, Matthew J. (2011) Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency Nature Materials, 10, (8), pp. 637-644. (doi:10.1038/nmat3058). (PMID:21765399).

Record type: Article

Abstract

There is currently an unmet need for the supply of autologous, patient-specific stem cells for regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by the material/cell interface suggesting a unique strategy to manipulate stem cells in the absence of complex soluble chemistries or cellular reprogramming. However, so far the derivation and identification of surfaces that allow retention of multipotency of this key regenerative cell type have remained elusive. Adult stem cells spontaneously differentiate in culture, resulting in a rapid diminution of the multipotent cell population and their regenerative capacity. Here we identify a nanostructured surface that retains stem-cell phenotype and maintains stem-cell growth over eight weeks. Furthermore, the study implicates a role for small RNAs in repressing key cell signalling and metabolomic pathways, demonstrating the potential of surfaces as non-invasive tools with which to address the stem cell niche.

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Published date: 17 July 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 197139
URI: http://eprints.soton.ac.uk/id/eprint/197139
ISSN: 1476-1122
PURE UUID: f36f3b61-d5aa-4b83-9215-f541360de12a
ORCID for Rahul Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 19 Sep 2011 09:46
Last modified: 18 Jul 2017 11:21

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Contributors

Author: Rebecca J. McMurray
Author: Nikolaj Gadegaard
Author: P. Monica Tsimbouri
Author: Karl V. Burgess
Author: Laura E. McNamara
Author: Rahul Tare ORCID iD
Author: Kate Murawski
Author: Emmajayne Kingham
Author: Matthew J. Dalby

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