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Recent developments in combinatorial organic synthesis

Recent developments in combinatorial organic synthesis
Recent developments in combinatorial organic synthesis
The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.
solid-phase synthesis, libraries, analogs, chemical biology, techniques and methods, toxicology, pharmaceutical science, drug discovery
1359-6446
47-55
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9

Ganesan, A. (2002) Recent developments in combinatorial organic synthesis. Drug Discovery Today, 7 (1), 47-55. (doi:10.1016/S1359-6446(02)00002-8).

Record type: Article

Abstract

The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.

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Published date: 1 January 2002
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Keywords: solid-phase synthesis, libraries, analogs, chemical biology, techniques and methods, toxicology, pharmaceutical science, drug discovery
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Identifiers

Local EPrints ID: 19741
URI: http://eprints.soton.ac.uk/id/eprint/19741
DOI: doi:10.1016/S1359-6446(02)00002-8
ISSN: 1359-6446
PURE UUID: cf595975-1ecc-4043-b501-84ede8a930ff

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Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:18

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Author: A. Ganesan

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