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A tandem Heck reaction leading to a 26-membered carbocycle

Harrowven, D. C., Woodcock, T. and Howes, P. D. (2002) A tandem Heck reaction leading to a 26-membered carbocycle Tetrahedron Letters, 43, (51), pp. 9327-9329. (doi:10.1016/S0040-4039(02)02343-2).

Record type: Article


Sequential inter- and intramolecular Heck reactions have been used to construct a 26-membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation.

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Published date: 16 December 2002
Keywords: palladium-catalyzed vinylation, phase-transfer conditions, organic halides, cyclic carbopalladation, solid support, cyclization, macrocyclization


Local EPrints ID: 19763
ISSN: 0040-4039
PURE UUID: c50c5709-bc9d-4286-9997-364b79185138

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Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:30

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Author: D. C. Harrowven
Author: T. Woodcock
Author: P. D. Howes

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