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International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis

International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis
International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis
The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group on Bone Marker Standards (WG-BMS) has evaluated the clinical potential of bone turnover markers (BTMs) in the prediction of fracture risk and for monitoring treatment. Research evidence suggests that BTMs may provide information on fracture risk independently from BMD, so that fracture risk prediction might be enhanced by their inclusion in assessment algorithms. The potential use of BTMs to predict the response to treatments for osteoporosis in the individual patient is also of great interest. Treatment-induced changes in specific markers account for a substantial proportion of fracture risk reduction. However, there is still a need for stronger evidence on which to base practice in both situations. IOF/IFCC recommends one bone formation marker (serum procollagen type I N propeptide, s-PINP) and one bone resorption marker (serum C-terminal cross-linking telopeptide of type I collagen, s-CTX) to be used as reference markers and measured by standardised assays in observational and intervention studies in order to enlarge the international experience of the application of markers to clinical medicine and to help resolve uncertainties over their clinical use.
bone mineral density, bone turnover markers, clinical risk factors, fracture risk, osteoporosis, reference standard
1434-6621
1271-1274
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Griesmacher, A.
b41031ff-7949-4909-9a12-0c0e5711209c
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Trenti, T.
448dc6f2-0690-40d5-bc25-a8d3e4ee621c
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Griesmacher, A.
b41031ff-7949-4909-9a12-0c0e5711209c
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Trenti, T.
448dc6f2-0690-40d5-bc25-a8d3e4ee621c
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587

Vasikaran, S., Cooper, C., Eastell, R., Griesmacher, A., Morris, H.A., Trenti, T. and Kanis, J.A. (2011) International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis. Clinical Chemistry and Laboratory Medicine, 49 (8), 1271-1274. (doi:10.1515/CCLM.2011). (PMID:21605012)

Record type: Article

Abstract

The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group on Bone Marker Standards (WG-BMS) has evaluated the clinical potential of bone turnover markers (BTMs) in the prediction of fracture risk and for monitoring treatment. Research evidence suggests that BTMs may provide information on fracture risk independently from BMD, so that fracture risk prediction might be enhanced by their inclusion in assessment algorithms. The potential use of BTMs to predict the response to treatments for osteoporosis in the individual patient is also of great interest. Treatment-induced changes in specific markers account for a substantial proportion of fracture risk reduction. However, there is still a need for stronger evidence on which to base practice in both situations. IOF/IFCC recommends one bone formation marker (serum procollagen type I N propeptide, s-PINP) and one bone resorption marker (serum C-terminal cross-linking telopeptide of type I collagen, s-CTX) to be used as reference markers and measured by standardised assays in observational and intervention studies in order to enlarge the international experience of the application of markers to clinical medicine and to help resolve uncertainties over their clinical use.

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More information

Published date: August 2011
Keywords: bone mineral density, bone turnover markers, clinical risk factors, fracture risk, osteoporosis, reference standard
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 197917
URI: http://eprints.soton.ac.uk/id/eprint/197917
ISSN: 1434-6621
PURE UUID: 0e12b284-0894-4e5a-9d2f-e99e85732e36
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 28 Sep 2011 14:32
Last modified: 17 Dec 2019 01:56

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Contributors

Author: S. Vasikaran
Author: C. Cooper ORCID iD
Author: R. Eastell
Author: A. Griesmacher
Author: H.A. Morris
Author: T. Trenti
Author: J.A. Kanis

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