The University of Southampton
University of Southampton Institutional Repository

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants

Danaei, Goodarz, Finucane, Mariel M., Lu, Yuan, Singh, Gitanjali M., Cowan, Melanie J., Paciorek, Christopher J., Lin, John K., Farzadfar, Farshad, Khang, Young-Ho, Stevens, Gretchen A., Rao, Mayuree, Ali, Mohammed K., Riley, Leanne M., Robinson, Carolyn A., Ezzati, Majid and Fall, Caroline H.D. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose) (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants The Lancet, 378, (9785), pp. 31-40. (doi:10.1016/S0140-6736(11)60679-X). (PMID:21705069).

Record type: Article

Abstract

Background: Data for trends in glycaemia and diabetes prevalence are needed to understand the effects of diet and lifestyle within populations, assess the performance of interventions, and plan health services. No consistent and comparable global analysis of trends has been done. We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories.

Methods: We obtained data from health examination surveys and epidemiological studies (370 country-years and 2·7 million participants). We converted systematically between different glycaemic metrics. For each sex, we used a Bayesian hierarchical model to estimate mean FPG and its uncertainty by age, country, and year, accounting for whether a study was nationally, subnationally, or community representative.

Findings: In 2008, global age-standardised mean FPG was 5·50 mmol/L (95% uncertainty interval 5·37–5·63) for men and 5·42 mmol/L (5·29–5·54) for women, having risen by 0·07 mmol/L and 0·09 mmol/L per decade, respectively. Age-standardised adult diabetes prevalence was 9·8% (8·6–11·2) in men and 9·2% (8·0–10·5) in women in 2008, up from 8·3% (6·5–10·4) and 7·5% (5·8–9·6) in 1980. The number of people with diabetes increased from 153 (127–182) million in 1980, to 347 (314–382) million in 2008. We recorded almost no change in mean FPG in east and southeast Asia and central and eastern Europe. Oceania had the largest rise, and the highest mean FPG (6·09 mmol/L, 5·73–6·49 for men; 6·08 mmol/L, 5·72–6·46 for women) and diabetes prevalence (15·5%, 11·6–20·1 for men; and 15·9%, 12·1–20·5 for women) in 2008. Mean FPG and diabetes prevalence in 2008 were also high in south Asia, Latin America and the Caribbean, and central Asia, north Africa, and the Middle East. Mean FPG in 2008 was lowest in sub-Saharan Africa, east and southeast Asia, and high-income Asia-Pacific. In high-income subregions, western Europe had the smallest rise, 0·07 mmol/L per decade for men and 0·03 mmol/L per decade for women; North America had the largest rise, 0·18 mmol/L per decade for men and 0·14 mmol/L per decade for women.

Interpretation: Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences. Effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae.

Funding: Bill & Melinda Gates Foundation and WHO.

Full text not available from this repository.

More information

Published date: 24 June 2011
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 198085
URI: http://eprints.soton.ac.uk/id/eprint/198085
PURE UUID: e8dc41a6-d35d-4a30-8bd5-905ca1c1ca5f

Catalogue record

Date deposited: 30 Sep 2011 13:28
Last modified: 18 Jul 2017 11:20

Export record

Altmetrics

Contributors

Author: Goodarz Danaei
Author: Mariel M. Finucane
Author: Yuan Lu
Author: Gitanjali M. Singh
Author: Melanie J. Cowan
Author: Christopher J. Paciorek
Author: John K. Lin
Author: Farshad Farzadfar
Author: Young-Ho Khang
Author: Gretchen A. Stevens
Author: Mayuree Rao
Author: Mohammed K. Ali
Author: Leanne M. Riley
Author: Carolyn A. Robinson
Author: Majid Ezzati

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×