Acoustic radiation forces for the manipulation of cells and particles
Acoustic radiation forces for the manipulation of cells and particles
Ultrasonic standing wave fields are able to trap and manipulate biological cells and other micron scale particles. The ability to levitate and move cells is of fundamental importance in a wide variety of life sciences applications. The gradients of pressure and velocity within a standing wave interact with small scatterers, such as cells, to generate time-averaged forces, in addition to the oscillatory acoustic forces. These steady-state radiation forces comprise:
i) a component that acts towards the acoustic velocity maximum for a dense scatterer (relative to the surrounding fluid) and
ii) a component that acts towards the acoustic pressure minimum for a relatively stiff particle.
The resultant of these components will move the majority of scatterers, such as cells in aqueous suspension, towards the pressure nodes of a plane standing wave.
This presentation discusses the second order terms that lead to the radiation forces and describes different approaches to modelling the forces, both numerical and analytical. The magnitude and scale of the potential wells that can be created within the standing waves complement other approaches to cell manipulation such as optical traps and dielectrophoresis. In addition, ultrasonic excitation is particularly suitable for integration into lab-on-a-chip devices and at low intensities cell damage has been shown to be negligible, making the approach ideal for handling biological cells in microfluidic devices.
A number of potential applications of the technology will be described, including filtration and concentration, biosensor enhancement, and fractionation of particles on the basis of size, material properties and geometry
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
January 2011
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Hill, Martyn
(2011)
Acoustic radiation forces for the manipulation of cells and particles.
AFPAC 2011: 10th Anglo-French Physical Acoustics Conference.
19 - 21 Jan 2001.
Record type:
Conference or Workshop Item
(Other)
Abstract
Ultrasonic standing wave fields are able to trap and manipulate biological cells and other micron scale particles. The ability to levitate and move cells is of fundamental importance in a wide variety of life sciences applications. The gradients of pressure and velocity within a standing wave interact with small scatterers, such as cells, to generate time-averaged forces, in addition to the oscillatory acoustic forces. These steady-state radiation forces comprise:
i) a component that acts towards the acoustic velocity maximum for a dense scatterer (relative to the surrounding fluid) and
ii) a component that acts towards the acoustic pressure minimum for a relatively stiff particle.
The resultant of these components will move the majority of scatterers, such as cells in aqueous suspension, towards the pressure nodes of a plane standing wave.
This presentation discusses the second order terms that lead to the radiation forces and describes different approaches to modelling the forces, both numerical and analytical. The magnitude and scale of the potential wells that can be created within the standing waves complement other approaches to cell manipulation such as optical traps and dielectrophoresis. In addition, ultrasonic excitation is particularly suitable for integration into lab-on-a-chip devices and at low intensities cell damage has been shown to be negligible, making the approach ideal for handling biological cells in microfluidic devices.
A number of potential applications of the technology will be described, including filtration and concentration, biosensor enhancement, and fractionation of particles on the basis of size, material properties and geometry
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Published date: January 2011
Venue - Dates:
AFPAC 2011: 10th Anglo-French Physical Acoustics Conference, 2001-01-19 - 2001-01-21
Organisations:
Mechatronics
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Local EPrints ID: 198261
URI: http://eprints.soton.ac.uk/id/eprint/198261
PURE UUID: a6d5668e-9c80-45fe-978b-ee17bb1f2f22
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Date deposited: 04 Oct 2011 09:17
Last modified: 11 Dec 2021 02:50
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