Particle separation with ultrasonic standing waves
Particle separation with ultrasonic standing waves
Ultrasonic standing wave fields are able to trap and manipulate biological cells and other micron scale particles. The ability to levitate and move cells is of fundamental importance in a wide variety of life sciences applications. The gradients of pressure and velocity within a standing wave interact with small scatterers, such as cells, to generate time-averaged forces, in addition to the oscillatory acoustic forces. These steady-state radiation forces comprise:
i) a component that acts towards the acoustic velocity maximum for a dense scatterer (relative to the surrounding fluid) and
ii) a component that acts towards the acoustic pressure minimum for a relatively stiff particle.
The resultant of these components will move the majority of scatterers, such as cells in aqueous suspension, towards the pressure nodes of a plane standing wave.
This presentation discusses the second order terms that lead to the radiation forces and describes different approaches to modelling the forces, both numerical and analytical. The magnitude and scale of the potential wells that can be created within the standing waves complement other approaches to cell manipulation such as optical traps and dielectrophoresis. In addition, ultrasonic excitation is particularly suitable for integration into lab-on-a-chip devices and at low intensities cell damage has been shown to be negligible, making the approach ideal for handling biological cells in microfluidic devices.
A number of potential applications of the technology will be described, including filtration and concentration, biosensor enhancement, and fractionation of particles on the basis of size, material properties and geometry
Glynne-Jones, P.
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Boltryk, R.J.
0452b21c-a758-4d4a-925b-1511d9296d62
Harris, N.R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
May 2011
Glynne-Jones, P.
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Boltryk, R.J.
0452b21c-a758-4d4a-925b-1511d9296d62
Harris, N.R.
237cfdbd-86e4-4025-869c-c85136f14dfd
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Glynne-Jones, P., Boltryk, R.J., Harris, N.R. and Hill, Martyn
(2011)
Particle separation with ultrasonic standing waves.
ICAS 2011: IUPAC International Congress on Analytical Sciences.
Record type:
Conference or Workshop Item
(Other)
Abstract
Ultrasonic standing wave fields are able to trap and manipulate biological cells and other micron scale particles. The ability to levitate and move cells is of fundamental importance in a wide variety of life sciences applications. The gradients of pressure and velocity within a standing wave interact with small scatterers, such as cells, to generate time-averaged forces, in addition to the oscillatory acoustic forces. These steady-state radiation forces comprise:
i) a component that acts towards the acoustic velocity maximum for a dense scatterer (relative to the surrounding fluid) and
ii) a component that acts towards the acoustic pressure minimum for a relatively stiff particle.
The resultant of these components will move the majority of scatterers, such as cells in aqueous suspension, towards the pressure nodes of a plane standing wave.
This presentation discusses the second order terms that lead to the radiation forces and describes different approaches to modelling the forces, both numerical and analytical. The magnitude and scale of the potential wells that can be created within the standing waves complement other approaches to cell manipulation such as optical traps and dielectrophoresis. In addition, ultrasonic excitation is particularly suitable for integration into lab-on-a-chip devices and at low intensities cell damage has been shown to be negligible, making the approach ideal for handling biological cells in microfluidic devices.
A number of potential applications of the technology will be described, including filtration and concentration, biosensor enhancement, and fractionation of particles on the basis of size, material properties and geometry
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More information
Published date: May 2011
Venue - Dates:
ICAS 2011: IUPAC International Congress on Analytical Sciences, 2011-05-01
Organisations:
Mechatronics
Identifiers
Local EPrints ID: 198267
URI: http://eprints.soton.ac.uk/id/eprint/198267
PURE UUID: 6a5ae398-5341-4ce0-a269-e8bb022e69ad
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Date deposited: 04 Oct 2011 10:19
Last modified: 07 Dec 2024 02:37
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Contributors
Author:
R.J. Boltryk
Author:
N.R. Harris
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