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Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase
Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase
Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar
1359-7345
11228-11230
Ioannou, Avgousta
b86f94bb-ce3f-4579-be8e-11d9cfa2da1e
Cini, Elena
d6050a68-9691-4fe3-a499-99c1b63a9459
Timofte, Roxana S.
3f3248ca-0730-48fe-b2b4-b6fa52b499f2
Flitsch, Sabine L.
74eec2dd-f329-4f0f-999d-73edbcf34e96
Turner, Nicholas J.
fbd8bc12-7f5e-4159-9718-8659a6a393d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Ioannou, Avgousta
b86f94bb-ce3f-4579-be8e-11d9cfa2da1e
Cini, Elena
d6050a68-9691-4fe3-a499-99c1b63a9459
Timofte, Roxana S.
3f3248ca-0730-48fe-b2b4-b6fa52b499f2
Flitsch, Sabine L.
74eec2dd-f329-4f0f-999d-73edbcf34e96
Turner, Nicholas J.
fbd8bc12-7f5e-4159-9718-8659a6a393d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba

Ioannou, Avgousta, Cini, Elena, Timofte, Roxana S., Flitsch, Sabine L., Turner, Nicholas J. and Linclau, Bruno (2011) Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase. Chemical Communications, 47 (40), 11228-11230. (doi:10.1039/c1cc13956h).

Record type: Article

Abstract

Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar

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e-pub ahead of print date: 13 September 2011
Organisations: Chemistry, Faculty of Natural and Environmental Sciences

Identifiers

Local EPrints ID: 198499
URI: http://eprints.soton.ac.uk/id/eprint/198499
ISSN: 1359-7345
PURE UUID: 616822ea-6baf-416e-a42a-fa91039e401b
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

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Date deposited: 03 Nov 2011 12:18
Last modified: 18 Feb 2021 16:55

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