Sollogoub, M., Fox, K. R., Powers, V. E. C. and Brown, T.
First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine
Tetrahedron Letters, 43, (17), . (doi:10.1016/S0040-4039(02)00481-1).
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The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides.
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