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First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine

Sollogoub, M., Fox, K. R., Powers, V. E. C. and Brown, T. (2002) First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine Tetrahedron Letters, 43, (17), pp. 3121-3123. (doi:10.1016/S0040-4039(02)00481-1).

Record type: Article


The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides.

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Published date: 22 April 2002
Keywords: glycosides, chemistry, pyridine


Local EPrints ID: 19860
ISSN: 0040-4039
PURE UUID: d2b17561-15ce-4833-9c23-effad6622b67
ORCID for K. R. Fox: ORCID iD

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Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:30

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Author: M. Sollogoub
Author: K. R. Fox ORCID iD
Author: V. E. C. Powers
Author: T. Brown

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