The stereospecific synthesis of 'orthogonally' protected lanthionines

Swali, V., Matteucci, M., Elliot, R. and Bradley, M. (2002) The stereospecific synthesis of 'orthogonally' protected lanthionines Tetrahedron, 58, (44), pp. 9101-9109. (doi:10.1016/S0040-4020(02)01091-8).


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Lanthionine is an attractive monomer for the design and synthesis of novel conformationally constrained peptidomimetics, since unlike cystine, the monosulfur bridge of lanthionine is chemically far more robust and also displays a greater degree of conformational rigidity. The synthesis of lanthionine residues for use in peptide synthesis is non-trivial due to the protectional requirements necessary for this tetra-functional amino acid. In this paper an efficient stereo-specific route to orthogonally protected lanthionine is described.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4020(02)01091-8
ISSNs: 0040-4020 (print)
Keywords: lanthionine, peptidomimetics, peptides organic sulfur chemistry, solid-phase synthesis, amino-acids, selectivedesulfurization, peptide-synthesis, n-tritylserine, derivatives, analogs, serine, esters
ePrint ID: 19864
Date :
Date Event
28 October 2002Published
Date Deposited: 17 Feb 2006
Last Modified: 16 Apr 2017 23:00
Further Information:Google Scholar

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