Regioselective synthesis of 3-alkylindoles mediated by zinc triflate
Regioselective synthesis of 3-alkylindoles mediated by zinc triflate
Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hunig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
3-substituted indoles, tryptophans
2705-2708
Zhu, X. W.
fad0ac04-78c6-4a45-820d-67b55e1a362b
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
19 April 2002
Zhu, X. W.
fad0ac04-78c6-4a45-820d-67b55e1a362b
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Zhu, X. W. and Ganesan, A.
(2002)
Regioselective synthesis of 3-alkylindoles mediated by zinc triflate.
Journal of Organic Chemistry, 67 (8), .
(doi:10.1021/jo010996b).
Abstract
Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hunig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
This record has no associated files available for download.
More information
Published date: 19 April 2002
Keywords:
3-substituted indoles, tryptophans
Identifiers
Local EPrints ID: 19873
URI: http://eprints.soton.ac.uk/id/eprint/19873
ISSN: 0022-3263
PURE UUID: 7ef5f926-239a-4e91-8392-17f20e6481c7
Catalogue record
Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:20
Export record
Altmetrics
Contributors
Author:
X. W. Zhu
Author:
A. Ganesan
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics