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Strategies for drug delivery to the human inner ear by multifunctional nanoparticles

Record type: Article

Hearing loss is a very significant health problem. The methods currently available for inner ear drug delivery are limited and a noninvasive cell-specific drug delivery strategy needs to be found.

Aim: in this study we investigated the ability of polymersomes, lipid core nanocapsules and hyperbranched poly-L-lysine to cross the round window membrane.

Materials & Methods: nanoparticles (NPs) used in this study have different size and chemical compositions. Freshly frozen human temporal bones were used for this investigation. Intact human round window membrane within the freshly frozen human temporal bone served as an excellent model to test the membrane permeation and distribution within the tissues.

Results: in this investigation we were able to visualize the NPs across the round window membrane. The NPs were subsequently found to be distributed in the sensory hair cells, nerve fibers and to other cells of the cochlea.

Conclusion: this finding raises hope in terms of future multifunctional NP-based drug delivery strategy to the human inner ear

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Citation

Roy, Soumen, Glueckert, Rudolf, Johnston, Alex H., Perrier, Thomas, Newman, T.A., Saulnier, Patrick and Schrott-Fischer, Anneliese (2012) Strategies for drug delivery to the human inner ear by multifunctional nanoparticles Nanomedicine, 7, (1), pp. 55-63. (doi:10.2217/nnm.11.84). (PMID:22106854).

More information

Accepted/In Press date: October 2011
Published date: January 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 198761
URI: http://eprints.soton.ac.uk/id/eprint/198761
ISSN: 1743-5889
PURE UUID: c57cef93-994c-4a51-96ff-f679d80ec448

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Date deposited: 06 Oct 2011 15:34
Last modified: 18 Jul 2017 11:18

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Contributors

Author: Soumen Roy
Author: Rudolf Glueckert
Author: Alex H. Johnston
Author: Thomas Perrier
Author: T.A. Newman
Author: Patrick Saulnier
Author: Anneliese Schrott-Fischer

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