Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene
Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene
The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS.
styrenic methoxypoly(ethylene glycol) (mpeg), monomer, resins, solid
supports, solid phase synthesissuspension polymerization, organic-synthesis, peptide-synthesis, supports, acid, catalysts, chemistry, polymers, beads
7163-7169
Alesso, S. M.
5c534080-d1ea-48c1-a305-ce1199612808
Yu, Z. R.
83833cf6-b575-4b4a-a0da-0118a91ff50e
Pears, D.
5072fd98-a99e-41a8-9a65-8cc4aaab951a
Worthington, P. A.
44871258-bd15-4224-82ac-5270d6fcd38a
Luke, R. W. A.
c412c683-6064-4ea9-9d0f-07d09b9fea03
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
1 September 2003
Alesso, S. M.
5c534080-d1ea-48c1-a305-ce1199612808
Yu, Z. R.
83833cf6-b575-4b4a-a0da-0118a91ff50e
Pears, D.
5072fd98-a99e-41a8-9a65-8cc4aaab951a
Worthington, P. A.
44871258-bd15-4224-82ac-5270d6fcd38a
Luke, R. W. A.
c412c683-6064-4ea9-9d0f-07d09b9fea03
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Alesso, S. M., Yu, Z. R., Pears, D., Worthington, P. A., Luke, R. W. A. and Bradley, M.
(2003)
Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene.
Tetrahedron, 59 (36), .
(doi:10.1016/S0040-4020(03)01100-1).
Abstract
The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS.
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Published date: 1 September 2003
Keywords:
styrenic methoxypoly(ethylene glycol) (mpeg), monomer, resins, solid
supports, solid phase synthesissuspension polymerization, organic-synthesis, peptide-synthesis, supports, acid, catalysts, chemistry, polymers, beads
Identifiers
Local EPrints ID: 19878
URI: http://eprints.soton.ac.uk/id/eprint/19878
ISSN: 0040-4020
PURE UUID: b4f840e6-397c-40ed-9042-bd831692793e
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Date deposited: 17 Feb 2006
Last modified: 15 Mar 2024 06:20
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Contributors
Author:
S. M. Alesso
Author:
Z. R. Yu
Author:
D. Pears
Author:
P. A. Worthington
Author:
R. W. A. Luke
Author:
M. Bradley
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