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Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene

Alesso, S. M., Yu, Z. R., Pears, D., Worthington, P. A., Luke, R. W. A. and Bradley, M. (2003) Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene Tetrahedron, 59, (36), pp. 7163-7169. (doi:10.1016/S0040-4020(03)01100-1).

Record type: Article


The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS.

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Published date: 1 September 2003
Keywords: styrenic methoxypoly(ethylene glycol) (mpeg), monomer, resins, solid supports, solid phase synthesissuspension polymerization, organic-synthesis, peptide-synthesis, supports, acid, catalysts, chemistry, polymers, beads


Local EPrints ID: 19878
ISSN: 0040-4020
PURE UUID: b4f840e6-397c-40ed-9042-bd831692793e

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Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:30

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Author: S. M. Alesso
Author: Z. R. Yu
Author: D. Pears
Author: P. A. Worthington
Author: R. W. A. Luke
Author: M. Bradley

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