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Trifluoroacetyl as an orthogonal protecting group for guanidines

Bartoli, S., Jensen, K. B. and Kilburn, J. D. (2003) Trifluoroacetyl as an orthogonal protecting group for guanidines Journal of Organic Chemistry, 68, (24), pp. 9416-9422. (doi:10.1021/jo0348874).

Record type: Article


The trifluoroacetyl moiety has been used as a new protecting group for guanidine functionality. The protecting group is easily cleaved under mild basic conditions and is complementary to the Boc, Cbz, and Ddpe protecting groups. The protecting group can be applied to peptide synthesis in solution as well as on a solid phase as it is orthogonal to a Boc and Cbz strategy and semiorthogonal to an Fmoc strategy.

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Published date: 28 November 2003
Keywords: molecular tweezers, carboxylic-acids, receptor, complexation, recognition, libraries, design, water


Local EPrints ID: 19893
ISSN: 0022-3263
PURE UUID: 28a3a5a3-75f2-47bb-9f2a-662ac0f0f5ba

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Date deposited: 20 Feb 2006
Last modified: 17 Jul 2017 16:30

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Author: S. Bartoli
Author: K. B. Jensen
Author: J. D. Kilburn

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