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Trifluoroacetyl as an orthogonal protecting group for guanidines

Bartoli, S., Jensen, K. B. and Kilburn, J. D. (2003) Trifluoroacetyl as an orthogonal protecting group for guanidines Journal of Organic Chemistry, 68, (24), pp. 9416-9422. (doi:10.1021/jo0348874).

Record type: Article

Abstract

The trifluoroacetyl moiety has been used as a new protecting group for guanidine functionality. The protecting group is easily cleaved under mild basic conditions and is complementary to the Boc, Cbz, and Ddpe protecting groups. The protecting group can be applied to peptide synthesis in solution as well as on a solid phase as it is orthogonal to a Boc and Cbz strategy and semiorthogonal to an Fmoc strategy.

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More information

Published date: 28 November 2003
Keywords: molecular tweezers, carboxylic-acids, receptor, complexation, recognition, libraries, design, water

Identifiers

Local EPrints ID: 19893
URI: http://eprints.soton.ac.uk/id/eprint/19893
ISSN: 0022-3263
PURE UUID: 28a3a5a3-75f2-47bb-9f2a-662ac0f0f5ba

Catalogue record

Date deposited: 20 Feb 2006
Last modified: 17 Jul 2017 16:30

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Contributors

Author: S. Bartoli
Author: K. B. Jensen
Author: J. D. Kilburn

University divisions

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