The University of Southampton
University of Southampton Institutional Repository

Site-site interactions within high-loading PAMAM dendrimer resin beads

Basso, A. and Bradley, M. (2003) Site-site interactions within high-loading PAMAM dendrimer resin beads Tetrahedron Letters, 44, (13), pp. 2699-2702. (doi:10.1016/S0040-4039(03)00374-5).

Record type: Article


Combinatorial chemistry and solid-phase synthesis have revolutionised the process of drug discovery in the last decade. Ever since the concept of split and mix synthesis was introduced in 1988, and in particular the concept of one bead one compound, this approach has been associated with the possibility of generating thousands or millions of compounds in only a relatively small number of synthetic steps. The demand for high loading resins has therefore increased over the last few years. Our research has focussed on bead-loading enhancement via a dendrimerisation process. Dendrimer resin beads have shown compatibility for many chemical conditions, however high functional group density could produce undesirable site-site interactions.

Full text not available from this repository.

More information

Published date: 24 March 2003
Keywords: solid-phase synthesis, dendrimer resin, site-site interactions solid-phase synthesis, organic-synthesis, ethers


Local EPrints ID: 19895
ISSN: 0040-4039
PURE UUID: d485a63d-7343-4e54-97aa-94d2d1bf7d70

Catalogue record

Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:30

Export record



Author: A. Basso
Author: M. Bradley

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.