The University of Southampton
University of Southampton Institutional Repository

Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients

Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients
Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients
Differently from what previously reported, we here demonstrate that all purine compounds, including uric acid, are elevated in biological fluids of MS patients. Reinforced by the trend observed for creatinine, this corroborates the notion of sustained purine catabolism, possibly due to imbalance in ATP homeostasis, under these pathological conditions. These results cast doubt on the hypothesis that uric acid is depleted in MS because of increased oxidative stress, rather suggesting that this disease causes a generalized increase in purine catabolism. As observed in other pathological states, uric acid, purine compounds and creatinine, can be considered markers of metabolic energy imbalance rather than of reactive oxygen species, even in MS.
0009-9120
1001-1006
Amorini, Angela M
3fb2d438-e4ef-44b3-9c51-1a198c7b7a2b
Petzold, Axel
f7d23dac-63d2-4b0c-a0c1-0c2e60cffdc1
Tavazzi, Barbara
22416dea-27d4-496d-8104-803bc0b0f13c
Eikelenboom, Judith
c70545a1-fd62-4a5f-803b-243e776f3249
Keir, Geoffrey
79b057ad-2942-4cdc-bf34-fd8e655b2f3a
Belli, Antonio
33707b7b-b004-4245-aead-98a8e1e2b2e2
Giovannoni, Gavin
8453ec93-f894-42f1-a1e1-6fa85589a5d0
Di Pietro, Valentina
52a26fb6-7579-4cdc-aee6-26cb6e9ff175
Polman, Chris
bf1cb4ab-51d6-48fa-be3a-522851041fd7
D'Urso, Serafina
30951fc2-bcf5-4c99-b4f7-2a7f040ac899
Vagnozzi, Roberto
3c1c46f7-9a64-459e-82cd-50cf9ee73a2e
Uitdehaag, Bernard
8fdbb67f-469f-4eae-8adf-c97683b65757
Lazzarino, Giuseppe
2344efe0-43bc-4781-9f72-451f3d7f407d
Amorini, Angela M
3fb2d438-e4ef-44b3-9c51-1a198c7b7a2b
Petzold, Axel
f7d23dac-63d2-4b0c-a0c1-0c2e60cffdc1
Tavazzi, Barbara
22416dea-27d4-496d-8104-803bc0b0f13c
Eikelenboom, Judith
c70545a1-fd62-4a5f-803b-243e776f3249
Keir, Geoffrey
79b057ad-2942-4cdc-bf34-fd8e655b2f3a
Belli, Antonio
33707b7b-b004-4245-aead-98a8e1e2b2e2
Giovannoni, Gavin
8453ec93-f894-42f1-a1e1-6fa85589a5d0
Di Pietro, Valentina
52a26fb6-7579-4cdc-aee6-26cb6e9ff175
Polman, Chris
bf1cb4ab-51d6-48fa-be3a-522851041fd7
D'Urso, Serafina
30951fc2-bcf5-4c99-b4f7-2a7f040ac899
Vagnozzi, Roberto
3c1c46f7-9a64-459e-82cd-50cf9ee73a2e
Uitdehaag, Bernard
8fdbb67f-469f-4eae-8adf-c97683b65757
Lazzarino, Giuseppe
2344efe0-43bc-4781-9f72-451f3d7f407d

Amorini, Angela M, Petzold, Axel, Tavazzi, Barbara, Eikelenboom, Judith, Keir, Geoffrey, Belli, Antonio, Giovannoni, Gavin, Di Pietro, Valentina, Polman, Chris, D'Urso, Serafina, Vagnozzi, Roberto, Uitdehaag, Bernard and Lazzarino, Giuseppe (2009) Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clinical Biochemistry, 42 (10-11), 1001-1006. (doi:10.1016/j.clinbiochem.2009.03.020). (PMID:19341721)

Record type: Article

Abstract

Differently from what previously reported, we here demonstrate that all purine compounds, including uric acid, are elevated in biological fluids of MS patients. Reinforced by the trend observed for creatinine, this corroborates the notion of sustained purine catabolism, possibly due to imbalance in ATP homeostasis, under these pathological conditions. These results cast doubt on the hypothesis that uric acid is depleted in MS because of increased oxidative stress, rather suggesting that this disease causes a generalized increase in purine catabolism. As observed in other pathological states, uric acid, purine compounds and creatinine, can be considered markers of metabolic energy imbalance rather than of reactive oxygen species, even in MS.

Full text not available from this repository.

More information

Published date: July 2009
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 199239
URI: https://eprints.soton.ac.uk/id/eprint/199239
ISSN: 0009-9120
PURE UUID: ea91ceb2-2a48-4f58-ad3e-04a7ce139cae

Catalogue record

Date deposited: 13 Oct 2011 09:28
Last modified: 16 Jul 2019 23:22

Export record

Altmetrics

Contributors

Author: Angela M Amorini
Author: Axel Petzold
Author: Barbara Tavazzi
Author: Judith Eikelenboom
Author: Geoffrey Keir
Author: Antonio Belli
Author: Gavin Giovannoni
Author: Valentina Di Pietro
Author: Chris Polman
Author: Serafina D'Urso
Author: Roberto Vagnozzi
Author: Bernard Uitdehaag
Author: Giuseppe Lazzarino

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×