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Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients

Amorini, Angela M, Petzold, Axel, Tavazzi, Barbara, Eikelenboom, Judith, Keir, Geoffrey, Belli, Antonio, Giovannoni, Gavin, Di Pietro, Valentina, Polman, Chris, D'Urso, Serafina, Vagnozzi, Roberto, Uitdehaag, Bernard and Lazzarino, Giuseppe (2009) Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients Clinical Biochemistry, 42, (10-11), pp. 1001-1006. (doi:10.1016/j.clinbiochem.2009.03.020). (PMID:19341721).

Record type: Article


Differently from what previously reported, we here demonstrate that all purine compounds, including uric acid, are elevated in biological fluids of MS patients. Reinforced by the trend observed for creatinine, this corroborates the notion of sustained purine catabolism, possibly due to imbalance in ATP homeostasis, under these pathological conditions. These results cast doubt on the hypothesis that uric acid is depleted in MS because of increased oxidative stress, rather suggesting that this disease causes a generalized increase in purine catabolism. As observed in other pathological states, uric acid, purine compounds and creatinine, can be considered markers of metabolic energy imbalance rather than of reactive oxygen species, even in MS.

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Published date: July 2009
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 199239
ISSN: 0009-9120
PURE UUID: ea91ceb2-2a48-4f58-ad3e-04a7ce139cae

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Date deposited: 13 Oct 2011 09:28
Last modified: 18 Jul 2017 11:16

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Author: Angela M Amorini
Author: Axel Petzold
Author: Barbara Tavazzi
Author: Judith Eikelenboom
Author: Geoffrey Keir
Author: Antonio Belli
Author: Gavin Giovannoni
Author: Valentina Di Pietro
Author: Chris Polman
Author: Serafina D'Urso
Author: Roberto Vagnozzi
Author: Bernard Uitdehaag
Author: Giuseppe Lazzarino

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