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A microfluidic device for the characterisation of embolisation with polyvinyl alcohol beads through biomimetic bifurcations

A microfluidic device for the characterisation of embolisation with polyvinyl alcohol beads through biomimetic bifurcations
A microfluidic device for the characterisation of embolisation with polyvinyl alcohol beads through biomimetic bifurcations
A microfluidic based device has been developed for the characterisation of embolisation behaviour with polyvinyl alcohol (PVA) hydrogel beads within a microchannel network with bifurcations which mimic the blood vessel network. Both distal and proximal embolisations were achieved within the PMMA-made microdevice exhibiting comparable embolisation characteristics with those observed in vivo. Results showed that small beads allowed more distal embolisations with a reduced control of the spatial location of occlusion sites. In contrast, large beads generated effective proximal embolisations with an improved reproducibility of embolisation performance. Embolic bead hydrodynamics, partitioning at bifurcations, penetration through microchannels and embolisation locations across the channel network were characterised by quantifying the effects of embolic bead size, bead concentration, channel geometry and fluidic conditions. This development provided further insights into the physical principles governing embolisation performances within the constructed microdevices allowing the improvement of the predictability and controllability of the clinical process outcomes. Furthermore, it can potentially provide a useful platform for preclinical research as an alternative to animal models, with an ultimate goal to reduce the amount of animal testing.
embolisation. polyvinyl alcohol hydrogel beads, microfluidics, bifurcation
1387-2176
153-163
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Capretto, Lorenzo
0f3586b5-1560-49c1-a76b-59e74ea600ef
Willis, Sean
c52887ff-55d1-4910-81db-dd70448db56f
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c
Grey, David
1c9bb5ce-c740-47d1-a82f-d2eeada1d6c7
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Capretto, Lorenzo
0f3586b5-1560-49c1-a76b-59e74ea600ef
Willis, Sean
c52887ff-55d1-4910-81db-dd70448db56f
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c
Grey, David
1c9bb5ce-c740-47d1-a82f-d2eeada1d6c7
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1

Carugo, Dario, Capretto, Lorenzo, Willis, Sean, Lewis, Andrew L., Grey, David, Hill, Martyn and Zhang, Xunli (2012) A microfluidic device for the characterisation of embolisation with polyvinyl alcohol beads through biomimetic bifurcations. Biomedical Microdevices, 14 (1), 153-163. (doi:10.1007/s10544-011-9593-8). (PMID:21987002)

Record type: Article

Abstract

A microfluidic based device has been developed for the characterisation of embolisation behaviour with polyvinyl alcohol (PVA) hydrogel beads within a microchannel network with bifurcations which mimic the blood vessel network. Both distal and proximal embolisations were achieved within the PMMA-made microdevice exhibiting comparable embolisation characteristics with those observed in vivo. Results showed that small beads allowed more distal embolisations with a reduced control of the spatial location of occlusion sites. In contrast, large beads generated effective proximal embolisations with an improved reproducibility of embolisation performance. Embolic bead hydrodynamics, partitioning at bifurcations, penetration through microchannels and embolisation locations across the channel network were characterised by quantifying the effects of embolic bead size, bead concentration, channel geometry and fluidic conditions. This development provided further insights into the physical principles governing embolisation performances within the constructed microdevices allowing the improvement of the predictability and controllability of the clinical process outcomes. Furthermore, it can potentially provide a useful platform for preclinical research as an alternative to animal models, with an ultimate goal to reduce the amount of animal testing.

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More information

e-pub ahead of print date: January 2012
Keywords: embolisation. polyvinyl alcohol hydrogel beads, microfluidics, bifurcation
Organisations: Engineering Science Unit

Identifiers

Local EPrints ID: 199869
URI: https://eprints.soton.ac.uk/id/eprint/199869
ISSN: 1387-2176
PURE UUID: b381c148-8815-4150-9b13-dc5eae63dd10
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571

Catalogue record

Date deposited: 21 Oct 2011 09:16
Last modified: 22 Sep 2019 00:34

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