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A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation

A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation
A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation
We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).
1359-7345
1620-1622
Stanley, C.E.
719f0bd2-dced-4df2-a9c1-c8a29f6f6f80
Elvira, K.S.
6718546e-1ef5-4809-a92b-c89ce056627e
Niu, X
f3d964fb-23b4-45db-92fe-02426e4e76fa
Gee, A.D.
94b4380f-1f68-4a72-9645-91923af83b84
Ces, O.
c698a6a8-166b-47ec-a1ac-f46aaab8c5cb
Edel, J.B.
ec1f3d5b-0f99-4c11-ab8a-f4256e03b0d6
deMello, A.J.
ad9b4842-b673-4c9c-8d6a-0ed637fb7755
Stanley, C.E.
719f0bd2-dced-4df2-a9c1-c8a29f6f6f80
Elvira, K.S.
6718546e-1ef5-4809-a92b-c89ce056627e
Niu, X
f3d964fb-23b4-45db-92fe-02426e4e76fa
Gee, A.D.
94b4380f-1f68-4a72-9645-91923af83b84
Ces, O.
c698a6a8-166b-47ec-a1ac-f46aaab8c5cb
Edel, J.B.
ec1f3d5b-0f99-4c11-ab8a-f4256e03b0d6
deMello, A.J.
ad9b4842-b673-4c9c-8d6a-0ed637fb7755

Stanley, C.E., Elvira, K.S., Niu, X, Gee, A.D., Ces, O., Edel, J.B. and deMello, A.J. (2010) A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation. Chemical Communications, 46 (10), 1620-1622. (doi:10.1039/b924897h).

Record type: Article

Abstract

We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

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More information

e-pub ahead of print date: 5 January 2010
Published date: 14 March 2010
Organisations: Mechatronics

Identifiers

Local EPrints ID: 199881
URI: http://eprints.soton.ac.uk/id/eprint/199881
ISSN: 1359-7345
PURE UUID: f4685673-9a42-4fc6-87bf-ed7f797b970d

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Date deposited: 21 Oct 2011 15:10
Last modified: 14 Mar 2024 04:18

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Contributors

Author: C.E. Stanley
Author: K.S. Elvira
Author: X Niu
Author: A.D. Gee
Author: O. Ces
Author: J.B. Edel
Author: A.J. deMello

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