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Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging

Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging
Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging
A versatile approach for the rapid prototyping of microfluidic devices suitable for use with FT-IRspectroscopic imaging is introduced. Device manufacture is based on the direct printing of paraffin onto the surface of an infrared transparent substrate, followed by encapsulation. Key features of this approach are low running costs, rapid production times, simplicity of design modifications and suitability for integration with FT-IR spectroscopic measurements. In the current experiments, the minimum width of channel walls was found to be ~120 ?m and ~200 when a 25 ?m and 12 ?m spacer is used, respectively. Water and poly(ethylene glycol) are used as model fluids in a laminar flow regime, and are imaged in both transmission and attenuated total reflection (ATR) modes. It is established that adoption of transmission mode measurements yields superior sensitivity whilst the ATR mode is more suitable for quantitative analysis using strong spectral absorption bands. Results indicate that devices manufactured using this approach are suitable for use with in situ FT-IRspectroscopic imaging.
1473-0197
2170-2174
Chan, K.L. Andrew
0d7bc0b4-b955-4bd5-bfda-ff541a4e69fa
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
de Mello, Andrew J.
cba23f1f-bc9b-494b-953d-e9514bb52f68
Kazarian, Sergei G.
8437260e-9a8d-4fee-90cc-43e4cb564a94
Chan, K.L. Andrew
0d7bc0b4-b955-4bd5-bfda-ff541a4e69fa
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
de Mello, Andrew J.
cba23f1f-bc9b-494b-953d-e9514bb52f68
Kazarian, Sergei G.
8437260e-9a8d-4fee-90cc-43e4cb564a94

Chan, K.L. Andrew, Niu, Xize, de Mello, Andrew J. and Kazarian, Sergei G. (2010) Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging. Lab on a Chip, 10 (16), 2170-2174. (doi:10.1039/c004246c).

Record type: Article

Abstract

A versatile approach for the rapid prototyping of microfluidic devices suitable for use with FT-IRspectroscopic imaging is introduced. Device manufacture is based on the direct printing of paraffin onto the surface of an infrared transparent substrate, followed by encapsulation. Key features of this approach are low running costs, rapid production times, simplicity of design modifications and suitability for integration with FT-IR spectroscopic measurements. In the current experiments, the minimum width of channel walls was found to be ~120 ?m and ~200 when a 25 ?m and 12 ?m spacer is used, respectively. Water and poly(ethylene glycol) are used as model fluids in a laminar flow regime, and are imaged in both transmission and attenuated total reflection (ATR) modes. It is established that adoption of transmission mode measurements yields superior sensitivity whilst the ATR mode is more suitable for quantitative analysis using strong spectral absorption bands. Results indicate that devices manufactured using this approach are suitable for use with in situ FT-IRspectroscopic imaging.

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More information

e-pub ahead of print date: 7 June 2010
Published date: 2010
Organisations: Mechatronics

Identifiers

Local EPrints ID: 199883
URI: https://eprints.soton.ac.uk/id/eprint/199883
ISSN: 1473-0197
PURE UUID: 15e565fb-30f7-4ecb-9044-2dd74c9350a4

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Date deposited: 21 Oct 2011 15:16
Last modified: 18 Jul 2017 11:15

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Contributors

Author: K.L. Andrew Chan
Author: Xize Niu
Author: Andrew J. de Mello
Author: Sergei G. Kazarian

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