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Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols

Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2003) Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols Tetrahedron Letters, 44, (7), pp. 1347-1349. (doi:10.1016/S0040-4039(02)02888-5).

Record type: Article


Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields.

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Published date: 10 February 2003
Keywords: cyclization
Organisations: Chemistry


Local EPrints ID: 20005
ISSN: 0040-4039
PURE UUID: 409180a4-8a91-4497-a2d6-420858a7ecab

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Date deposited: 20 Feb 2006
Last modified: 17 Jul 2017 16:29

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Author: M. Lamberto
Author: D. F. Corbett
Author: J. D. Kilburn

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