Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols

Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2003) Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols. Tetrahedron Letters, 44 (7), 1347-1349. (doi:10.1016/S0040-4039(02)02888-5).

Record type: Article

Abstract

Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields.

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Published date: 10 February 2003

Keywords: cyclization

Organisations: Chemistry

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Identifiers

Local EPrints ID: 20005

URI: http://eprints.soton.ac.uk/id/eprint/20005

DOI: doi:10.1016/S0040-4039(02)02888-5

ISSN: 0040-4039

PURE UUID: 409180a4-8a91-4497-a2d6-420858a7ecab

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Date deposited: 20 Feb 2006

Last modified: 15 Mar 2024 06:21

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Contributors

Author: M. Lamberto

Author: D. F. Corbett

Author: J. D. Kilburn

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