Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers
Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers
Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation.
solid-phase chemistry, dendrimers, high-loading, multivalency, isocyanatehigh-loading resin, peptide-synthesis, beads, chemistry
3945-3953
Lebreton, S.
565a2f7b-c948-4c19-a7d5-704413341ef2
How, S. E.
fd4a1274-c838-4aaf-a5fc-6b024b0bf664
Buchholz, M.
45681423-2037-48c9-be3c-fbe5ad3bf4f8
Yingyongnarongkul, B. E.
ebde2428-8226-4887-992e-daebeb8eeffa
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
26 May 2003
Lebreton, S.
565a2f7b-c948-4c19-a7d5-704413341ef2
How, S. E.
fd4a1274-c838-4aaf-a5fc-6b024b0bf664
Buchholz, M.
45681423-2037-48c9-be3c-fbe5ad3bf4f8
Yingyongnarongkul, B. E.
ebde2428-8226-4887-992e-daebeb8eeffa
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Lebreton, S., How, S. E., Buchholz, M., Yingyongnarongkul, B. E. and Bradley, M.
(2003)
Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers.
Tetrahedron, 59 (22), .
(doi:10.1016/S0040-4020(03)00463-0).
Abstract
Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation.
This record has no associated files available for download.
More information
Published date: 26 May 2003
Keywords:
solid-phase chemistry, dendrimers, high-loading, multivalency, isocyanatehigh-loading resin, peptide-synthesis, beads, chemistry
Identifiers
Local EPrints ID: 20008
URI: http://eprints.soton.ac.uk/id/eprint/20008
ISSN: 0040-4020
PURE UUID: 6200e365-d172-4066-9b8d-bcb2d7b0a512
Catalogue record
Date deposited: 17 Feb 2006
Last modified: 15 Mar 2024 06:21
Export record
Altmetrics
Contributors
Author:
S. Lebreton
Author:
S. E. How
Author:
M. Buchholz
Author:
B. E. Yingyongnarongkul
Author:
M. Bradley
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics