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Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers

Record type: Article

Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation.

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Lebreton, S., How, S. E., Buchholz, M., Yingyongnarongkul, B. E. and Bradley, M. (2003) Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers Tetrahedron, 59, (22), pp. 3945-3953. (doi:10.1016/S0040-4020(03)00463-0).

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Published date: 26 May 2003
Keywords: solid-phase chemistry, dendrimers, high-loading, multivalency, isocyanatehigh-loading resin, peptide-synthesis, beads, chemistry


Local EPrints ID: 20008
ISSN: 0040-4020
PURE UUID: 6200e365-d172-4066-9b8d-bcb2d7b0a512

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Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:29

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Author: S. Lebreton
Author: S. E. How
Author: M. Buchholz
Author: B. E. Yingyongnarongkul
Author: M. Bradley

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