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Antibacterial single-bead screening

Record type: Article

Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.

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Citation

Lebreton, S., Newcombe, N. and Bradley, M. (2003) Antibacterial single-bead screening Tetrahedron, 59, (51), pp. 10213-10222. (doi:10.1016/j.tet.2003.10.070).

More information

Published date: 15 December 2003
Keywords: beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands

Identifiers

Local EPrints ID: 20009
URI: http://eprints.soton.ac.uk/id/eprint/20009
ISSN: 0040-4020
PURE UUID: 535e68e2-37e5-437c-a1c0-57da7799ad4b

Catalogue record

Date deposited: 17 Feb 2006
Last modified: 17 Jul 2017 16:29

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Contributors

Author: S. Lebreton
Author: N. Newcombe
Author: M. Bradley

University divisions


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