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Pyridoxal phosphate: biosynthesis and catabolism

Mukherjee, Tathagata, Hanes, Jeremiah, Tews, Ivo, Ealick, Steven E. and Begley, Tadhg P. (2011) Pyridoxal phosphate: biosynthesis and catabolism [in special issue: Pyridoxal Phosphate Enzymology] Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814, (11), pp. 1585-1596. (doi:10.1016/j.bbapap.2011.06.018). (PMID:21767669).

Record type: Article


Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.

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e-pub ahead of print date: 8 July 2011
Published date: November 2011
Keywords: plp, vitamin B6, dxp dependent pathway, R5P pathway, vitamin B6 catabolism
Organisations: Centre for Biological Sciences


Local EPrints ID: 200223
ISSN: 1570-9639
PURE UUID: 22d2d14d-3885-488b-8198-c7a10ee5f43d
ORCID for Ivo Tews: ORCID iD

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Date deposited: 24 Oct 2011 11:21
Last modified: 18 Jul 2017 11:14

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Author: Tathagata Mukherjee
Author: Jeremiah Hanes
Author: Ivo Tews ORCID iD
Author: Steven E. Ealick
Author: Tadhg P. Begley

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