The University of Southampton
University of Southampton Institutional Repository

A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens

Rice, Jason and Christodoulides, Myron (2011) A DNA vaccine strategy for effective antibody induction to pathogen-derived antigens Methods in Molecular Biology, 799, pp. 405-419. (doi:10.1007/978-1-61779-346-2_22). (PMID:21993657).

Record type: Article


DNA-based vaccines are currently being developed for treating a diversity of human diseases including cancers, autoimmune conditions, allergies, and microbial infections. In this chapter, we present a general protocol that can be used as a starting point for developing DNA vaccines to pathogen-derived antigens, using Neisseria meningitidis as an example. In addition, we describe a fusion gene-based vaccine protocol for increasing the potency of DNA vaccines that are based on poorly immunogenic antigens such as short pathogen-derived polypeptides. Finally, we provide a safe and effective protocol for delivery of DNA vaccines, based on intramuscular injection followed by electroporation.

Full text not available from this repository.

More information

Published date: 19 October 2011
Keywords: dna vaccine, neutralizing humoral antibody, t cell help, infectious disease
Organisations: Cancer Sciences


Local EPrints ID: 200257
PURE UUID: 46b783bf-a54d-4f4d-b136-28373d94511b

Catalogue record

Date deposited: 24 Oct 2011 14:33
Last modified: 18 Jul 2017 11:14

Export record



Author: Jason Rice

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.