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Orthopaedic biofilm infections

Orthopaedic biofilm infections
Orthopaedic biofilm infections
A recent paradigm shift in microbiology affects orthopaedic surgery and most other medical and dental disciplines because more than 65% of bacterial infections treated by clinicians in the developed world are now known to be caused by organisms growing in biofilms. These slime-enclosed communities of bacteria are inherently resistant to host defenses and to conventional antibacterial therapy, and these device-related and other chronic bacterial infections are unaffected by the vaccines and antibiotics that have virtually eliminated acute infections caused by planktonic (floating) bacteria. We examine the lessons that can be learned, within this biofilm paradigm, by the study of problems (e.g., non-culturability) shared by all biofilm infections and by the study of new therapeutic options aimed specifically at sessile bacteria in biofilms. Orthopaedic surgery has deduced some of the therapeutic strategies based on assiduous attention to patient outcomes, but much can still be learned by attention to modern research in related disciplines in medicine and dentistry. These perceptions will lead to practical improvements in the detection, management, and treatment of infections in orthopaedic surgery.
antibiotic resistance, biofilm, chronic infection, diagnosis, surgical debridement
1940-7041
558-563
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Ehrlich, Garth D.
aa8e5162-77a6-4627-a793-acd724ed0782
Sedghizadeh, Parish P.
6d723981-42d5-4c59-805e-a0d4bcd9a532
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Baratz, Mark E.
f0d1e79d-59d5-4846-8e1c-f36e6193e427
Altman, Daniel T.
d41303fd-f94d-410c-adc7-fb828e5aceb0
Sotereanos, Nicholas G.
826c42da-c093-4a32-a0e4-9a0e8b54912e
William Costerton, John
6755d61f-01f8-4404-b32f-016bbaaa5fbf
DeMeo, Patrick
a4b02685-ce16-41c2-8052-8202bb8b9d09
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Ehrlich, Garth D.
aa8e5162-77a6-4627-a793-acd724ed0782
Sedghizadeh, Parish P.
6d723981-42d5-4c59-805e-a0d4bcd9a532
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Baratz, Mark E.
f0d1e79d-59d5-4846-8e1c-f36e6193e427
Altman, Daniel T.
d41303fd-f94d-410c-adc7-fb828e5aceb0
Sotereanos, Nicholas G.
826c42da-c093-4a32-a0e4-9a0e8b54912e
William Costerton, John
6755d61f-01f8-4404-b32f-016bbaaa5fbf
DeMeo, Patrick
a4b02685-ce16-41c2-8052-8202bb8b9d09

Stoodley, Paul, Ehrlich, Garth D., Sedghizadeh, Parish P., Hall-Stoodley, Luanne, Baratz, Mark E., Altman, Daniel T., Sotereanos, Nicholas G., William Costerton, John and DeMeo, Patrick (2011) Orthopaedic biofilm infections Current Orthopaedic Practice, 22, (6), pp. 558-563. (doi:10.1097/BCO.0b013e318230efcf).

Record type: Article

Abstract

A recent paradigm shift in microbiology affects orthopaedic surgery and most other medical and dental disciplines because more than 65% of bacterial infections treated by clinicians in the developed world are now known to be caused by organisms growing in biofilms. These slime-enclosed communities of bacteria are inherently resistant to host defenses and to conventional antibacterial therapy, and these device-related and other chronic bacterial infections are unaffected by the vaccines and antibiotics that have virtually eliminated acute infections caused by planktonic (floating) bacteria. We examine the lessons that can be learned, within this biofilm paradigm, by the study of problems (e.g., non-culturability) shared by all biofilm infections and by the study of new therapeutic options aimed specifically at sessile bacteria in biofilms. Orthopaedic surgery has deduced some of the therapeutic strategies based on assiduous attention to patient outcomes, but much can still be learned by attention to modern research in related disciplines in medicine and dentistry. These perceptions will lead to practical improvements in the detection, management, and treatment of infections in orthopaedic surgery.

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More information

Published date: November 2011
Keywords: antibiotic resistance, biofilm, chronic infection, diagnosis, surgical debridement
Organisations: nCATS Group, Centre for Biological Sciences

Identifiers

Local EPrints ID: 200399
URI: http://eprints.soton.ac.uk/id/eprint/200399
ISSN: 1940-7041
PURE UUID: 15c8006e-240b-4b6a-9f91-307125dd2ff9

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Date deposited: 25 Oct 2011 10:42
Last modified: 18 Jul 2017 11:14

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Contributors

Author: Paul Stoodley
Author: Garth D. Ehrlich
Author: Parish P. Sedghizadeh
Author: Luanne Hall-Stoodley
Author: Mark E. Baratz
Author: Daniel T. Altman
Author: Nicholas G. Sotereanos
Author: John William Costerton
Author: Patrick DeMeo

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