Association of vitamin D status with knee pain and radiographic knee osteoarthritis

Muraki, S., Dennison, E .M., Jameson, K., Boucher, B. J., Akune, T., Yoshimura, N., Judge, A., Arden, N. K., Javaid, K. and Cooper, C. (2011) Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 19 (11), 1301-1306. (doi:10.1016/j.joca.2011.07.017). (PMID:PMID:21884812)

Abstract

Objective: The objective of the present study was to explore the association of serum vitamin D
concentration and polymorphism in the vitamin D receptor (VDR), with knee pain and radiographic knee
osteoarthritis (OA) among men and women in a large population-based UK cohort study.
Methods: Seven hundred and eighty-seven participants in the Hertfordshire Cohort Study (399 men, 388
women; mean age 65.6 ? 2.7 years) underwent a questionnaire on knee pain and radiographic knee
examination. This study examined the association of Fok1, Cdx2 and Apa1 polymorphism in the gene for
the VDR and serum 25(OH)D concentration with knee pain and radiographic knee OA by a generalized
estimating equations population averaged logistic regression analysis in the Hertfordshire Cohort Study.
Results: There were no associations of Fok1, Cdx2 and Apa1 polymorphisms of the VDR with knee OA
except for Aa for Apa1 compared with AA [Odds ratio (OR) 0.59, 95% confidence interval (CI) 0.36e0.95,
P¼ 0.031]. While, ff for Fok1 (OR 1.60, 95% CI 1.07e2.39, P¼ 0.022) and AA for Cdx2 polymorphism (OR
2.21, 95% CI 1.07e4.56, P¼ 0.032) was significantly associated with higher prevalence of knee pain
compared with FF for Fok1 and GG for Cdx2, respectively. None of these are statistically significant after
adjusting for the three polymorphisms tested. 25(OH)D level was not significantly associated with
radiographic knee OA, while, low tertile of 25(OH)D level tended to be associated with knee pain
compared with high tertile of 25(OH)D level.
Conclusion: The present cross-sectional study using a large-scale population from the Hertfordshire
Cohort study indicated that vitamin D may be associated with pain rather than radiographic change, but
the evidence for an association between vitamin D genetic variation and pain in knee OA is very weak in
the present study. Further replication of our results will be required to elucidate the association of
vitamin D and knee OA.

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Contributors

Author: E .M. Dennison

Author: C. Cooper

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