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Association of vitamin D status with knee pain and radiographic knee osteoarthritis

Association of vitamin D status with knee pain and radiographic knee osteoarthritis
Association of vitamin D status with knee pain and radiographic knee osteoarthritis
Objective: The objective of the present study was to explore the association of serum vitamin D
concentration and polymorphism in the vitamin D receptor (VDR), with knee pain and radiographic knee
osteoarthritis (OA) among men and women in a large population-based UK cohort study.
Methods: Seven hundred and eighty-seven participants in the Hertfordshire Cohort Study (399 men, 388
women; mean age 65.6 ? 2.7 years) underwent a questionnaire on knee pain and radiographic knee
examination. This study examined the association of Fok1, Cdx2 and Apa1 polymorphism in the gene for
the VDR and serum 25(OH)D concentration with knee pain and radiographic knee OA by a generalized
estimating equations population averaged logistic regression analysis in the Hertfordshire Cohort Study.
Results: There were no associations of Fok1, Cdx2 and Apa1 polymorphisms of the VDR with knee OA
except for Aa for Apa1 compared with AA [Odds ratio (OR) 0.59, 95% confidence interval (CI) 0.36e0.95,
P¼ 0.031]. While, ff for Fok1 (OR 1.60, 95% CI 1.07e2.39, P¼ 0.022) and AA for Cdx2 polymorphism (OR
2.21, 95% CI 1.07e4.56, P¼ 0.032) was significantly associated with higher prevalence of knee pain
compared with FF for Fok1 and GG for Cdx2, respectively. None of these are statistically significant after
adjusting for the three polymorphisms tested. 25(OH)D level was not significantly associated with
radiographic knee OA, while, low tertile of 25(OH)D level tended to be associated with knee pain
compared with high tertile of 25(OH)D level.
Conclusion: The present cross-sectional study using a large-scale population from the Hertfordshire
Cohort study indicated that vitamin D may be associated with pain rather than radiographic change, but
the evidence for an association between vitamin D genetic variation and pain in knee OA is very weak in
the present study. Further replication of our results will be required to elucidate the association of
vitamin D and knee OA.
knee osteoarthritis, gene polymorphism, epidemiology
1063-4584
1301-1306
Muraki, S.
d9b6df18-df2b-4e3c-bc56-2ee1be8fa7b1
Dennison, E .M.
ee647287-edb4-4392-8361-e59fd505b1d1
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Boucher, B. J.
0dcd9476-36b1-4e21-9052-eaf1adc6b13f
Akune, T.
be6a9357-40a2-4aa2-8284-756d4daa3010
Yoshimura, N.
a10d916f-afc1-4f89-a7e3-a690e16b4cdd
Judge, A.
c6a83964-1d7c-4aa8-b2bf-9c264d1e487d
Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f
Javaid, K.
8bf26a7a-1432-4bbf-a01f-9fd0f9b8c7ac
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Muraki, S.
d9b6df18-df2b-4e3c-bc56-2ee1be8fa7b1
Dennison, E .M.
ee647287-edb4-4392-8361-e59fd505b1d1
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Boucher, B. J.
0dcd9476-36b1-4e21-9052-eaf1adc6b13f
Akune, T.
be6a9357-40a2-4aa2-8284-756d4daa3010
Yoshimura, N.
a10d916f-afc1-4f89-a7e3-a690e16b4cdd
Judge, A.
c6a83964-1d7c-4aa8-b2bf-9c264d1e487d
Arden, N. K.
23af958d-835c-4d79-be54-4bbe4c68077f
Javaid, K.
8bf26a7a-1432-4bbf-a01f-9fd0f9b8c7ac
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Muraki, S., Dennison, E .M., Jameson, K., Boucher, B. J., Akune, T., Yoshimura, N., Judge, A., Arden, N. K., Javaid, K. and Cooper, C. (2011) Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 19 (11), 1301-1306. (doi:10.1016/j.joca.2011.07.017). (PMID:PMID:21884812)

Record type: Article

Abstract

Objective: The objective of the present study was to explore the association of serum vitamin D
concentration and polymorphism in the vitamin D receptor (VDR), with knee pain and radiographic knee
osteoarthritis (OA) among men and women in a large population-based UK cohort study.
Methods: Seven hundred and eighty-seven participants in the Hertfordshire Cohort Study (399 men, 388
women; mean age 65.6 ? 2.7 years) underwent a questionnaire on knee pain and radiographic knee
examination. This study examined the association of Fok1, Cdx2 and Apa1 polymorphism in the gene for
the VDR and serum 25(OH)D concentration with knee pain and radiographic knee OA by a generalized
estimating equations population averaged logistic regression analysis in the Hertfordshire Cohort Study.
Results: There were no associations of Fok1, Cdx2 and Apa1 polymorphisms of the VDR with knee OA
except for Aa for Apa1 compared with AA [Odds ratio (OR) 0.59, 95% confidence interval (CI) 0.36e0.95,
P¼ 0.031]. While, ff for Fok1 (OR 1.60, 95% CI 1.07e2.39, P¼ 0.022) and AA for Cdx2 polymorphism (OR
2.21, 95% CI 1.07e4.56, P¼ 0.032) was significantly associated with higher prevalence of knee pain
compared with FF for Fok1 and GG for Cdx2, respectively. None of these are statistically significant after
adjusting for the three polymorphisms tested. 25(OH)D level was not significantly associated with
radiographic knee OA, while, low tertile of 25(OH)D level tended to be associated with knee pain
compared with high tertile of 25(OH)D level.
Conclusion: The present cross-sectional study using a large-scale population from the Hertfordshire
Cohort study indicated that vitamin D may be associated with pain rather than radiographic change, but
the evidence for an association between vitamin D genetic variation and pain in knee OA is very weak in
the present study. Further replication of our results will be required to elucidate the association of
vitamin D and knee OA.

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More information

Published date: November 2011
Keywords: knee osteoarthritis, gene polymorphism, epidemiology
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 200421
URI: http://eprints.soton.ac.uk/id/eprint/200421
ISSN: 1063-4584
PURE UUID: c18ba52d-e7e1-454a-a463-6a64808bd0a7
ORCID for E .M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 25 Oct 2011 10:03
Last modified: 18 Feb 2021 16:48

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Contributors

Author: S. Muraki
Author: E .M. Dennison ORCID iD
Author: K. Jameson
Author: B. J. Boucher
Author: T. Akune
Author: N. Yoshimura
Author: A. Judge
Author: N. K. Arden
Author: K. Javaid
Author: C. Cooper ORCID iD

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