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Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines

Andrews, Nick J., Walker, Woolf T., Finn, Adam, Heath, Paul T., Collinson, Andrew C., Pollard, Andrew J., Snape, Matthew D., Faust, S.N., Waight, Pauline A., Hoschler, Katja, Sheasby, Liz, Waddington, Claire, Kerridge, Simon, Chalk, Jeremy, Reiner, Amanda, John, Tessa, Fletcher, Margaret, Allen, Ruth, Fineman, Natalie, Wilkins, Su, Casey, Michelle, Michaelis, Louise, Oeser, Clarissa, Okike, Ifeanyichukwu, Ladhani, Shamez and Miller, Elizabeth (2011) Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines Vaccine, 29, (45), pp. 7913-7919. (doi:10.1016/j.vaccine.2011.08.076). (PMID:21875635).

Record type: Article


In 2009, 943 children aged 6 months to 10 years were randomised to receive two doses of an oil-in water AS03B-adjuvanted split virion or a non-adjuvanted whole virion H1N1 (2009) vaccine. The large numbers allowed investigation of possible predictors of immune response and reactogenicity. We used regression analysis to examine the effect of variables including past receipt of seasonal vaccine, antipyretics post-vaccination, interval between doses and pre-existing antibodies to H1N1 (2009) on immunogenicity. We also examined the relationship between immunogenicity and reactogenicity and whether prior infection or underlying conditions affected reactogenicity. For both vaccines, haemagglutination-inhibition titres were 60% higher in children with fever ?38 °C after vaccination and 29% lower in those previously given seasonal vaccine. Early use of antipyretics did not affect immunogenicity. Post-vaccination titres were higher with longer intervals between doses and in those with evidence of prior infection, but reactogenicity in the latter was unaffected. In the adjuvanted vaccine group, reactions were more common in children with atopy. Both vaccines were safe and immunogenic in those with prior infection. Reduction in the interval between doses for earlier protection would be at the cost of reduced immunogenicity. The effect of seasonal vaccine on immunogenicity merits further investigation.

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e-pub ahead of print date: 27 August 2011
Published date: 19 October 2011
Keywords: pandemic vaccine, reactogenicity, immunogenicity, fever, atopy
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 200439
PURE UUID: c8787f0d-c372-4164-aa77-a300e5bd06e6
ORCID for S.N. Faust: ORCID iD

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Date deposited: 25 Oct 2011 13:14
Last modified: 18 Jul 2017 11:14

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Author: Nick J. Andrews
Author: Woolf T. Walker
Author: Adam Finn
Author: Paul T. Heath
Author: Andrew C. Collinson
Author: Andrew J. Pollard
Author: Matthew D. Snape
Author: S.N. Faust ORCID iD
Author: Pauline A. Waight
Author: Katja Hoschler
Author: Liz Sheasby
Author: Claire Waddington
Author: Simon Kerridge
Author: Jeremy Chalk
Author: Amanda Reiner
Author: Tessa John
Author: Margaret Fletcher
Author: Ruth Allen
Author: Natalie Fineman
Author: Su Wilkins
Author: Michelle Casey
Author: Louise Michaelis
Author: Clarissa Oeser
Author: Ifeanyichukwu Okike
Author: Shamez Ladhani
Author: Elizabeth Miller

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